At the center of Home Again is Madelaine - a brilliant cardiologist, a loving mother, a tender friend, and a woman full of self-doubt. It is also the story of her confused and angry daughter, Lina, and of the two very different men Madelaine loves: Francis, a priest searching for his faith, and Angel, a talented but cynical man with a broken heart. When tragedy suddenly brings them all together, they must learn to forgive the betrayals of the past and find the courage to love again.

Elizabeth and Jackson Shore married young, raised two daughters, and weathered the storms of youth as they built a future together. But after the children leave home, they quietly drift apart. When Jack accepts a wonderful new job offer, Elizabeth puts her needs aside to follow him across the country. Until the sudden death of her father changes everything.

Thirty-four-year-old Ruby Bridge is a not-too-successful comedienne who uses her mother, a nationally-syndicated "moral and spiritual counselor" as the main fodder for her cynical, rather bitter humor. Her mother Nora, long divorced from Ruby's father, is a woman whose past is just about to catch up with her - in the form of blackmail by a former lover.

The Grey sisters had only each other when their mother died years ago. Their father provided for them physically on Water's Edge, the ranch that had been in their family for three generations, each of them however, longed for their father's love.

Years of trying unsuccessfully to conceive a child have broken more than Angie DeSaria’s heart. Following a painful divorce, she moves back to her small Pacific Northwest hometown and takes over management of her family’s restaurant. In West End, where life rises and falls like the tides, Angie’s fortunes will drastically change yet again when she meets and befriends a troubled young woman.

Like many couples, Michael and Jolene Zarkades have to face the pressures of everyday life—children, careers, bills, chores—even as their twelve-year marriage is falling apart. Then a deployment sends Jolene deep into harm's way and leaves defense attorney Michael at home, unaccustomed to being a single parent to their two girls. As a mother, it agonizes Jolene to leave her family, but as a solider, she has always understood the true meaning of duty. In her letters home, she paints a rose-colored version of her life on the front lines, shielding her family from the truth.

On the day her daughter leaves for college, Anne Colwater's husband of 20 years announces he wants a divorce. Her roles of wife and mother suddenly gone, Annie retreats to her childhood home of Mystic, Washington, to heal. There she finds her old friend Nick, suddenly widowed and unable to cope with his emotionally scarred young daughter, Izzie.

In the rugged Pacific Northwest lies the Olympic National Forest - nearly a million acres of impenetrable darkness and impossible beauty. From deep within this old growth forest, a six-year-old girl appears. Speechless and alone, she offers no clue as to her identity, no hint of her past.

Meredith and Nina Whitson are as different as sisters can be. One stayed at home to raise her children and manage the family apple orchard; the other followed a dream and traveled the world to become a famous photojournalist. But when their beloved father falls ill, Meredith and Nina find themselves together again, standing alongside their cold, disapproving mother, Anya, who even now, offers no comfort to her daughters.

Joy Candellaro once loved Christmas more than any other time of the year. Now, as the holiday approaches, she is at a crossroads in her life; recently divorced and alone, she can’t summon the old enthusiasm for celebrating. So without telling anyone, she buys a ticket and boards a plane bound for the beautiful Pacific Northwest. When an unexpected detour takes her deep into the woods of the Olympic rainforest, Joy makes a bold decision to leave her ordinary life behind - to just walk away - and thus begins an adventure unlike any she could have imagined.

Texas, 1921. A time of abundance. The Great War is over, the bounty of the land is plentiful, and America is on the brink of a new and optimistic era. But for Elsa Wolcott, deemed too old to marry in a time when marriage is a woman’s only option, the future seems bleak. Until the night she meets Rafe Martinelli. By 1934, the world has changed; millions are out of work and drought has devastated the Great Plains. Elsa must make an agonizing choice: fight for the land she loves or leave it behind and go west, to California, in search of a better life for her family.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.

The Bodine ranch and resort in western Montana is a family business, an idyllic spot for vacationers. A little over thirty thousand acres and home to four generations, it’s kept running by Bodine Longbow with the help of a large staff, including new hire Callen Skinner. There was another member of the family once: Bodine’s aunt, Alice, who ran off before Bodine was born.

When an impossibly shy young woman named Judy Morgan finishes her studies in Physics at Cambridge University, it is with dreams of changing the world for the better. Meanwhile, a beautiful, young Jewish woman decides to flee her beloved Austria, changing her name to Hedy Lamarr, and risking everything to get to America, as far away from the Nazi threat as possible.

Women can be heroes. When twenty-year-old nursing student Frances “Frankie” McGrath hears these words, it is a revelation. Raised in the sun-drenched, idyllic world of Southern California and sheltered by her conservative parents, she has always prided herself on doing the right thing. But in 1965, the world is changing, and she suddenly dares to imagine a different future for herself. When her brother ships out to serve in Vietnam, she joins the Army Nurse Corps and follows his path.