Crippled by lupus at 25, celebrated author Flannery O'Connor was forced to leave New York City and return home to Andalusia, her family farm in Milledgeville, Georgia. Years later, as Flannery is finishing a novel and tending to her menagerie of peacocks, her mother drags her to the wedding of a family friend....

One summer morning, twelve-year-old Edward Adler, his beloved older brother, his parents, and 183 other passengers board a flight in Newark headed for Los Angeles. Among them are a Wall Street wunderkind, a young woman coming to terms with an unexpected pregnancy, an injured veteran returning from Afghanistan, a business tycoon, and a free-spirited woman running away from her controlling husband. Halfway across the country, the plane crashes. Edward is the sole survivor.

In this “rich, complex family saga” (USA Today) full of long-buried family secrets, Marilyn Connolly and David Sorenson fall in love in the 1970s, blithely ignorant of all that awaits them. By 2016, they have four radically different daughters, each in a state of unrest.

Meghan Michaels is trying to find balance between being a single mom and working full time as an ICU nurse, when a patient named Caitlin arrives in her ward with a traumatic brain injury. They say she jumped from a bridge and plunged over twenty feet to the train tracks below.

When Abraham Verghese, a physician whose marriage is unraveling, relocates to El Paso, Texas, he hopes to make a fresh start as a staff member at the county hospital. There he meets David Smith, a medical student recovering from drug addiction, and the two men begin a tennis ritual that allows them to shed their inhibitions and find security in the sport they love and with each other. This friendship between doctor and intern grows increasingly rich and complex, more intimate than two men usually allow.