Located in a nameless desert somewhere in the great American Southwest, Night Vale is a small town where ghosts, angels, aliens, and government conspiracies are all commonplace parts of everyday life. It is here that the lives of two women, with two mysteries, will converge.

Nilanjana Sikdar is an outsider to the town of Night Vale. Working for Carlos, the town's top scientist, she relies on fact and logic as her guiding principles. But all of that is put into question when Carlos gives her a special assignment investigating a mysterious rumbling in the desert wasteland outside of town. This investigation leads her to the Joyous Congregation of the Smiling God and to Darryl, one of its most committed members.

Esther Gold loves Halloween more than anything in the world. So she is determined to go trick-or-treating again this year despite the fact that her parents think she is officially too old. Esther has it all planned out, from her costume to her candy-collecting strategy. But when the night rolls around, something feels...off. No one is answering their door. The moon is an unnatural shade of orange. Strange children wander the streets, wearing creepy costumes that might not be costumes at all.

It is 1951, and at number six Sycamore Street, fifteen-year-old Edie Green is lonely. Living with her eccentric mother and her mother's new boyfriend, she is desperate for something to shake her from her dull, isolated life. So when the popular, pretty Lucy Theddle befriends Edie, she thinks all her troubles are over. Even though Lucy has a secret, one Edie is not certain she should keep. Then Lucy goes missing. Now in 2018, Edie is eighty-four and still living in the same small town, when one afternoon she glimpses Lucy Theddle, still looking the same as she did at fifteen.

Whales begin sinking ships. Toxic eyeless crabs poison Long Island’s water supply. Around the world, countries are beginning to feel the effects of the ocean’s revenge. In this riveting novel, full of twists, turns, and cliffhangers, a team of scientists discovers a strange, intelligent life force called the Yrr that takes form in marine animals in order to wreak havoc on man for his abuses.