Four young women have been found murdered—tortured and strangled in their own beds—all victims of the same brilliant monster. Using a skilled hand and the latest technology in forensic medicine, Kay Scarpetta begins the process of gathering the microscopic clues the latest battered body has to give.

While fighting in Afghanistan, Major Grant Barrett receives devastating news: his brother and sister-in-law have been murdered in Scarlet Falls, the sleepy suburb of Grant's youth. Emotionally scarred from war, the career soldier returns home on emergency leave to temporarily care for his orphaned nephew and niece. But when someone tries to kidnap the kids and their teenage babysitter, Grant knows it's not a random act... and neither were the murders.

Forensic pathologist Dr. Kay Scarpetta has come almost full circle, returning to Virginia, the state where she launched her storied career, as the chief medical examiner. Finding herself the new girl in town once again after being away for many years, she’s inherited both an overbearing secretary and a legacy of neglect and potential corruption.

It's June in Montreal, and Dr. Temperance Brennan, who has left a shaky marriage back home in North Carolina to take on the challenging assignment of Director of Forensic Anthropology for the province of Quebec, looks forward to a relaxing weekend in beautiful Quebec City. First, though, she must stop at a newly uncovered burial site in the heart of the city. The remains are probably old and only of archeological interest, but Tempe must make sure they're not a case for the police. One look at the decomposed and decapitated corpse, stored neatly in plastic bags, tells her she'll spend the weekend in the crime lab.

On the eve of a top secret space mission, Captain Calli Chase detects a tripped alarm in the tunnels deep below a NASA research center. A NASA pilot, quantum physicist, and cybercrime investigator, Calli knows that a looming blizzard and government shutdown could provide the perfect cover for sabotage, with deadly consequences. As it turns out, the danger is worse than she thought. A spatter of dried blood, a missing security badge, a suspicious suicide—a series of disturbing clues point to Calli’s twin sister, Carme, who’s been MIA for days.