Twelve year old Jake's middle school is about to be shut down—unless Jake and his friends can figure out how to save it. When Jake spies a bowl of jellybeans at the hotel where his mom works, he eats them. But those weren't just jellybeans. One of the scientists at his mom's conference is developing the world's first ingestible information pills. And that's what Jake ate.

"Are you a gifted child looking for special opportunities?" Dozens of children respond to this peculiar ad in the newspaper and are then put through a series of mind-bending tests, which readers take along with them. Only four children—two boys and two girls—succeed. Their challenge: to go on a secret mission that only the most intelligent and inventive children could complete. To accomplish it they will have to go undercover at the Learning Institute for the Very Enlightened, where the only rule is that there are no rules.

Florian is 12 years old and has just moved to Washington. He's learning his way around using TOAST, which stands for the Theory of All Small Things. It's a technique he invented to solve life's little mysteries. But when he teaches it to his new friend Margaret, they uncover a mystery that isn't little. In fact, it's huge, and it involves the National Gallery, the FBI, and a notorious crime syndicate known as EEL. Can Florian decipher the clues and finish his homework in time to help the FBI solve the case?

Cameron Boxer is very happy to spend his life avoiding homework, hanging out with his friends, and gaming for hours in his basement. It's not too hard for him to get away with it...until he gets so caught up in one game that he almost lets his house burn down around him. Oops. It's time for some serious damage control - so Cameron and his friends invent a fake school club that will make it seem like they're doing good deeds instead of slacking off. The problem? Some kids think the club is real.

Sara Martinez is a hacker. She recently broke into the New York City foster care system to expose her foster parents as cheats and lawbreakers. However, instead of being hailed as a hero, Sara finds herself facing years in a juvenile detention facility and banned from using computers for the same stretch of time. Enter Mother, a British spy who not only gets Sara released from jail but also offers her a chance to make a home for herself within a secret MI5 agency. Operating out of a base in Scotland, the City Spies are five kids from various parts of the world.