Located in a nameless desert somewhere in the great American Southwest, Night Vale is a small town where ghosts, angels, aliens, and government conspiracies are all commonplace parts of everyday life. It is here that the lives of two women, with two mysteries, will converge.

Nilanjana Sikdar is an outsider to the town of Night Vale. Working for Carlos, the town's top scientist, she relies on fact and logic as her guiding principles. But all of that is put into question when Carlos gives her a special assignment investigating a mysterious rumbling in the desert wasteland outside of town. This investigation leads her to the Joyous Congregation of the Smiling God and to Darryl, one of its most committed members.

Born at the end of the old world, Miriam grows up during The Great Reckoning, a sprawling, decades-long war that nearly decimates humanity and strips her of friends and family. Devastated by grief and loneliness, she emotionally exiles herself, avoiding relationships or allegiances, and throws herself into her work - disengagement that serves her when the war finally ends, and The New Society arises.

Esther Gold loves Halloween more than anything in the world. So she is determined to go trick-or-treating again this year despite the fact that her parents think she is officially too old. Esther has it all planned out, from her costume to her candy-collecting strategy. But when the night rolls around, something feels...off. No one is answering their door. The moon is an unnatural shade of orange. Strange children wander the streets, wearing creepy costumes that might not be costumes at all.

The unicorn lived in a lilac wood, and she lived all alone...so she ventured out from the safety of the enchanted forest on a quest for others of her kind. Joined along the way by the bumbling magician Schmendrick and the indomitable Molly Grue, the unicorn learns all about the joys and sorrows of life and love before meeting her destiny in the castle of a despondent monarch—and confronting the creature that would drive her kind to extinction....