The Ultimates - the first government-sponsored cadre of super heroes - was assembled to face threats to humanity too insanely powerful for other operatives to handle. But even the Ultimates are unprepared for a quintet of mysterious visitors who appear in the midst of the team's top-security base of operations, claiming to be emissaries from the future. These "Tomorrow Men" say Earth's civilization are at a crossroads - on the verge of enslavement by a secret, immensely efficient organization known in the future as Tiber.

Betrayed by Earth's heroes and exiled into outer space, the man-monster known as the Incredible Hulk has landed on the distant planet Sakaar, ruled by the tyrannical Red King. Sold into slavery, the Hulk becomes the Green Scar, the planet's mightiest gladiator! But his new masters get more than they bargained for when he forges a bond of brotherhood with his fellow fighters: crafty insectoid Miek, the horrific Brood, wise rock-man Korg, Shadow Warrior Hiroim, noble-born rebel Elloe, and her loyal guardsman Skee. Together, these gladiators start a revolution.

Born to a rarified breed of Russian aristocracy, Kraven the Hunter had stalked and killed every animal known to man and considered himself the world's best big-game hunter. It was this confidence that brought him to New York years ago, in an obsessive quest to hunt what he considered the city's greatest prey: Spider-Man. But his target eluded him time and again, mocking him at every turn.

Cyclops and Emma Frost re-form the team with the express purpose of "astonishing" the world. But when breaking news regarding the mutant gene unexpectedly hits the airwaves, will it derail their new plans before they even get started? As demand for the "mutant cure" reaches near-riot levels, the X-Men go head-to-head with the enigmatic Ord, with an unexpected ally - and some unexpected adversaries - tipping the scales!

The alien shapeshifters called the Chitauri were defeated by the Ultimates in a decisive battle, but suspicious activity leads the Ultimates to believe that not all of the aliens were destroyed in that cataclysmic attack. Stark Industries has developed means of quickly and easily detecting Chitauri DNA, but the federal government refuses to adopt the technology, claiming that if the tech is widely available, the Chitauri will find a way to fool it. Frustrated by the government’s seeming unwillingness to protect its own people, Captain America takes matters into his own hands.