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Summary of Jennifer A. Doudna & Samuel H. Sternberg’s A Crack in Creation
- Narrated by: Chad Louwerse
- Length: 26 mins
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Summary of Jennifer A. Doudna & Samuel H. Sternberg’s A Crack in Creation
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Publisher's Summary
No time to read? Get the main key insights from this summary of Jennifer A. Doudna and Samuel H. Sternberg’s A Crack in Creation in just a short listen.
A few key insights from Chapter 1:
1. In 1983, biologist Jack Szostak discovered a repair mechanism for breaks in the double strand of DNA.
2. The famous structure of DNA is the double helix, which consists of two strands. In the repair procedure, it is broken by enzymes before a corrected copy of DNA is inserted, which facilitates the healthy copy’s incorporation.
3. By inducing a local double-strand break in the DNA, the genome can be corrected. When the break is introduced, the cell attempts to repair the damage, finding the synthetic gene ready at hand to replace the defective one that was broken.
4. With this discovery, a new challenge arose. Scientists had to find the right enzyme that would break the genome at the right site, singling out the right DNA sequence out of billions of similar sequences.