In the long awaited follow-up to the highly praised novel She's Come Undone, Dominick Birdsey must come to terms with himself, as well as with the schizophrenic twin brother he has spent his life both protecting and resenting.

When high-school teacher Caelum Quirk and his wife, Maureen, move to Littleton, Colorado, they both get jobs at Columbine High School. In April 1999, while Caelum is away, Maureen finds herself in the library at Columbine, cowering in a cabinet and expecting to be killed. Miraculously, she survives. But when Caelum and Maureen flee to an illusion of safety on the Quirk family's Connecticut farm, they discover that the effects of chaos are not easily put right.

After 27 years of marriage and three children, Anna Oh - wife, mother, outsider artist - has fallen in love with Viveca, the wealthy Manhattan art dealer who orchestrated her success. They plan to wed in the Oh family’s hometown of Three Rivers in Connecticut. But the wedding provokes some very mixed reactions and opens a Pandora’s Box of toxic secrets - dark and painful truths that have festered below the surface of the Ohs' lives.

Maine, 1789: When the Kennebec River freezes, entombing a man in the ice, Martha Ballard is summoned to examine the body and determine cause of death. As a midwife and healer, she is privy to much of what goes on behind closed doors in Hallowell. Her diary is a record of every birth and death, crime and debacle that unfolds in the close-knit community. Months earlier, Martha documented the details of an alleged rape committed by two of the town’s most respected gentlemen—one of whom has now been found dead in the ice.

Margaret Simon, almost 12, has just moved from New York City to the suburbs, and she’s anxious to fit in with her new friends. When she’s asked to join a secret club, she jumps at the chance. But when the girls start talking about boys, bras, and getting their first periods, Margaret starts to wonder if she’s normal. There are some things about growing up that are hard for her to talk about, even with her friends. Lucky for Margaret, she’s got someone else to confide in...someone who always listens.