Sixteen-year-old Nomi Nickel longs to hang out with Lou Reed and Marianne Faithfull in New York City's East Village. Instead she's trapped in East Village, Manitoba, a small town whose population is Mennonite: "the most embarrassing sub-sect of people to belong to if you're a teenager." East Village is a town with no train and no bar whose job prospects consist of slaughtering chickens at the Happy Family Farms abattoir or churning butter for tourists at the pioneer village.

Days after being dumped by her boyfriend Marc in Paris - "he was heading off to an ashram and said we could communicate telepathically" - Hattie hears her sister Min has been checked into a psychiatric hospital, and finds herself flying back to Winnipeg to take care of Thebes and Logan, her niece and nephew. Not knowing what else to do, they set out on a road trip in search of the children's long-lost father, Cherkis. On their wayward journey, the Troutmans stay at scary motels, meet helpful hippies, and try to ignore the threatening noises coming from under the hood of their van.

Newlyweds Celestial and Roy are the embodiment of both the American Dream and the New South. He is a young executive, and she is an artist on the brink of an exciting career. But as they settle into the routine of their life together, they are ripped apart by circumstances neither could have imagined. Roy is arrested and sentenced to 12 years for a crime Celestial knows he didn't commit. Though fiercely independent, Celestial finds herself bereft and unmoored, taking comfort in Andre, her childhood friend, and best man at their wedding.

Christophe has been in the New World only a year when his native guides abandon him to flee their Iroquois pursuers. A Huron warrior and elder named Bird soon takes him prisoner, along with a young Iroquois girl, Snow Falls, whose family he has just killed, and holds them captive in his massive village. Champlain's Iron People have only recently begun trading with the Huron, who mistrust them as well as this Crow who has now trespassed onto their land; and her people, of course, have become the Huron's greatest enemy.

A girl grows up in Nunavut in the 1970s. She knows joy and friendship and parents' love. She knows boredom and listlessness and bullying. She knows the tedium of the everyday world and the raw, amoral power of the ice and sky, the seductive energy of the animal world. She knows the ravages of alcohol and violence at the hands of those she should be able to trust. She sees the spirits that surround her and the immense power that dwarfs all of us. When she becomes pregnant, she must navigate all this.