It’s 2 AM on a Saturday night in the spring of 2001, and 28-year-old Cecily Gardner sits alone in a dive bar in New York’s East Village, questioning her life. Feeling lonesome and homesick for the Midwest, she wonders if she’ll ever make it as a reporter in the big city - and whether she made a terrible mistake in breaking up with her longtime boyfriend, Matthew. 

Tessa Russo is the mother of two young children and the wife of a renowned pediatric surgeon. Despite her own mother's warnings, Tessa has recently given up her career to focus on her family and the pursuit of domestic happiness. From the outside, she seems destined to live a charmed life. Valerie Anderson is an attorney and single mother to six-year-old Charlie - a boy who has never known his father.

The Kingsley family is American royalty, beloved for their military heroics, political service, and unmatched elegance. In 1967, after Joseph S. Kingsley, Jr. is killed in a tragic accident, his charismatic son inherits the weight of that legacy. But Joe III is a free spirit—and a little bit reckless. Despite his best intentions, he has trouble meeting the expectations of a nation, as well as those of his exacting mother, Dottie.

Thirty-three-year-old Shea Rigsby has spent her entire life in Walker, Texas - a small college town that lives and dies by football, a passion she unabashedly shares. Raised alongside her best friend, Lucy, the daughter of Walker’s legendary head coach, Clive Carr, Shea was too devoted to her hometown team to leave. Instead she stayed in Walker for college, even taking a job in the university athletic department after graduation, where she has remained for more than a decade.

Marian Caldwell is a 36-year-old television producer, living her dream in New York City. With a fulfilling career and satisfying relationship, she has convinced everyone, including herself, that her life is just as she wants it to be. But one night, Marian answers a knock on the door ... only to find Kirby Rose, an 18-year-old girl with a key to a past that Marian thought she had sealed off forever. From the moment Kirby appears on her doorstep, Marian’s perfectly constructed world - and her very identity - will be shaken to its core.

After being together for 10 years, Sylvie and Dan have all the trimmings of a happy life and marriage; they have a comfortable home, fulfilling jobs, and beautiful twin girls and communicate so seamlessly, they finish each other's sentences. However, a trip to the doctor projects they will live another 68 years together, and panic sets in. They never expected "until death do us part" to mean seven decades. In the name of marriage survival, they quickly concoct a plan to keep their relationship fresh and exciting.

Growing up, Josie and Meredith Garland shared a loving, if sometimes contentious, relationship. Josie was impulsive, spirited, and outgoing, Meredith hardworking, thoughtful, and reserved. When tragedy strikes, their delicate bond splinters. Fifteen years later, Josie and Meredith are in their late 30s, following very different paths.  

Ellen's relationship to Andy doesn't just seem perfect on the surface; it really is perfect. She loves his family, and everything about him, including that he brings out the best in her. That is, until Ellen unexpectedly runs into Leo. The one who got away. The one who brought out the worst in her. The one she can't forget.

Poppy Wyatt has never felt luckier. She is about to marry her ideal man, Magnus Tavish, but in one afternoon her “happily ever after” begins to fall apart. Not only has she lost her engagement ring in a hotel fire drill but in the panic that follows, her phone is stolen. As she paces shakily around the lobby, she spots an abandoned phone in a trash can. Finders keepers! Now she can leave a number for the hotel to contact her when they find her ring. Perfect! Well, perfect except that the phone’s owner, businessman Sam Roxton, doesn’t agree.

Laurie is sure love at first sight doesn't exist anywhere but the movies. But then, through a misted-up bus window one snowy December day, she sees a man who she knows instantly is the one. Their eyes meet, there's a moment of pure magic...and then her bus drives away. Certain they're fated to find each other again, Laurie spends a year scanning every bus stop and cafe in London for him. But she doesn't find him, not when it matters anyway. Instead they "reunite" at a Christmas party, when her best friend, Sarah, giddily introduces her new boyfriend: the man from the bus.

Fixie Farr has always lived by her father’s motto: “Family first”. And since her dad passed away, leaving his charming housewares store in the hands of his wife and children, Fixie spends all her time picking up the slack from her siblings instead of striking out on her own. When a handsome stranger in a coffee shop asks her to watch his laptop for a moment, she not only agrees - she ends up saving it from certain disaster. To thank Fixie for her quick thinking, the computer’s owner, an investment manager, scribbles an IOU on a coffee sleeve and attaches his business card.

It’s been almost two years since Effie’s beloved parents got divorced, destroying the image of the happy, loving childhood she thought she had. Since then, she’s become estranged from her father and embarked on a feud with his hot (and much younger) girlfriend, Krista. And now, more earth-shattering news: They’ve sold Greenoaks, the rambling Victorian country house Effie has always called home.

Six years after the fight that ended their friendship, Daphne Berg is shocked when Drue Cavanaugh walks back into her life, looking as lovely and successful as ever, with a massive favor to ask. Daphne hasn’t spoken one word to Drue in all this time - she doesn’t even hate-follow her ex-best friend on social media - so when Drue asks if she will be her maid-of-honor at the society wedding of the summer, Daphne is rightfully speechless.

Addie Downs and Valerie Adler will be best friends forever. That’s what Addie believes after Valerie moves across the street when they’re both nine years old. But in their teenage years, Val is swept into the popular crowd. Flash-forward 15 years. Addie Downs lives alone in her parents’ house, caring for a troubled brother and trying to meet Prince Charming on the Internet. she opens her door to find her long-gone best friend standing there, a terrified look on her face and blood on the sleeve of her coat.

Daisy Shoemaker can’t sleep. With a thriving cooking business, full schedule of volunteer work, and a beautiful home in the Philadelphia suburbs, she should be content. But her teenage daughter can be a handful, her husband can be distant, her work can feel trivial, and she has lots of acquaintances, but no real friends. Still, Daisy knows she’s got it good. So why is she up all night?