It’s 2 a.m. on a Saturday night in the spring of 2001, and 28-year-old Cecily Gardner sits alone in a dive bar in New York’s East Village, questioning her life. Feeling lonesome and homesick for the Midwest, she wonders if she’ll ever make it as a reporter in the big city - and whether she made a terrible mistake in breaking up with her longtime boyfriend, Matthew. As Cecily reaches for the phone to call him, she hears a guy on the barstool next to her say, “Don’t do it - you’ll regret it.” Something tells her to listen.

Thirty-three-year-old Shea Rigsby has spent her entire life in Walker, Texas - a small college town that lives and dies by football, a passion she unabashedly shares. Raised alongside her best friend, Lucy, the daughter of Walker’s legendary head coach, Clive Carr, Shea was too devoted to her hometown team to leave. Instead she stayed in Walker for college, even taking a job in the university athletic department after graduation, where she has remained for more than a decade.

Tessa Russo is the mother of two young children and the wife of a renowned pediatric surgeon. Despite her own mother's warnings, Tessa has recently given up her career to focus on her family and the pursuit of domestic happiness. From the outside, she seems destined to live a charmed life. Valerie Anderson is an attorney and single mother to six-year-old Charlie - a boy who has never known his father.

Growing up, Josie and Meredith Garland shared a loving, if sometimes contentious, relationship. Josie was impulsive, spirited, and outgoing, Meredith hardworking, thoughtful, and reserved. When tragedy strikes, their delicate bond splinters. Fifteen years later, Josie and Meredith are in their late 30s, following very different paths.  

Marian Caldwell is a 36-year-old television producer, living her dream in New York City. With a fulfilling career and satisfying relationship, she has convinced everyone, including herself, that her life is just as she wants it to be. But one night, Marian answers a knock on the door ... only to find Kirby Rose, an 18-year-old girl with a key to a past that Marian thought she had sealed off forever. From the moment Kirby appears on her doorstep, Marian’s perfectly constructed world - and her very identity - will be shaken to its core.

After being together for 10 years, Sylvie and Dan have all the trimmings of a happy life and marriage; they have a comfortable home, fulfilling jobs, and beautiful twin girls and communicate so seamlessly, they finish each other's sentences. However, a trip to the doctor projects they will live another 68 years together, and panic sets in. They never expected "until death do us part" to mean seven decades. In the name of marriage survival, they quickly concoct a plan to keep their relationship fresh and exciting.

Ava thinks love should be found in the real world, not on apps that filter men by height, job, or astrological sign. She believes in feelings, not algorithms. So after a recent breakup and dating app debacle, she decides to put love on hold and escapes to a remote writers' retreat in coastal Italy. At the retreat, she's not allowed to use her real name or reveal any personal information. When the neighboring martial arts retreat is canceled and a few of its attendees join their small writing community, Ava, now going by "Aria", meets "Dutch", a man who seems too good to be true.

Minnie Cooper knows two things with certainty: that her New Year's birthday is unlucky, and that it's all because of Quinn Hamilton, a man she's never met. Their mothers gave birth to them at the same hospital just after midnight on New Year's Day, but Quinn was given the cash prize for being the first baby born in London in 1990 - and the name Minnie was meant to have, as well. With luck like that, it's no wonder each of her birthdays has been more of a disaster than the one before. 

Darcy Rhone thought she had it all figured out: the more beautiful the girl, the more charmed her life. Never mind substance. Never mind playing by the rules. Never mind karma. But Darcy's neat, perfect world turns upside down when her best friend, Rachel, the plain-Jane “good girl,” steals her fiancé, while Darcy finds herself completely alone for the first time in her life . . . with a baby on the way. Darcy tries to recover, fleeing to her childhood friend living in London and resorting to her tried-and-true methods for getting what she wants.

Six years after the fight that ended their friendship, Daphne Berg is shocked when Drue Cavanaugh walks back into her life, looking as lovely and successful as ever, with a massive favor to ask. Daphne hasn’t spoken one word to Drue in all this time - she doesn’t even hate-follow her ex-best friend on social media - so when Drue asks if she will be her maid-of-honor at the society wedding of the summer, Daphne is rightfully speechless.

On an island off the coast of Ireland, guests gather to celebrate two people joining their lives together as one. The groom: handsome and charming, a rising television star. The bride: smart and ambitious, a magazine publisher. It’s a wedding for a magazine or for a celebrity: the designer dress, the remote location, the luxe party favors, the boutique whiskey. The cell phone service may be spotty and the waves may be rough, but every detail has been expertly planned and will be expertly executed.

Welcome to Greenwich, CT, where the lawns are manicured, the Long Island iced teas are extra strong, and heads turn when an infamous new neighbor arrives for an extended long weekend. After Emily Charlton left Miranda Priestly and Runway magazine, she migrated to L.A with her husband, working as an image consultant to the stars. But recently Emily's lost a few clients. She's struggling. When the opportunity arrives to reinvent and relaunch a gorgeous former model whose mugshot graces the cover of the New York Post, Emily jumps at the chance. Relaunching Karolina is the big leagues.

Ellen's relationship to Andy doesn't just seem perfect on the surface; it really is perfect. She loves his family, and everything about him, including that he brings out the best in her. That is, until Ellen unexpectedly runs into Leo. The one who got away. The one who brought out the worst in her. The one she can't forget.

Becky still adores the traditions of Christmas: Her parents host, carols play on repeat, her mother pretends she made the Christmas pudding, and the neighbors come ’round for sherry in their terrible holiday sweaters. Things are looking cheerier than ever, until Becky’s parents announce they’re moving to ultra-trendy Shoreditch - unable to resist the draw of craft beer and smashed avocados - and ask Becky if she’ll host this year. What could possibly go wrong? 

When Mallory Blessing's son, Link, receives deathbed instructions from his mother to call a number on a slip of paper in her desk drawer, he's not sure what to expect. But he certainly does not expect Jake McCloud to answer. It's the late spring of 2020 and Jake's wife, Ursula DeGournsey, is the frontrunner in the upcoming Presidential election. There must be a mistake, Link thinks. How do Mallory and Jake know each other?