At Granite's Mill, deep in the backwoods of Virginia, a body is discovered with unusual physical characteristics. By morning, the media erupts over a headline in a local newspaper, "The Son of Virginia's Governor is Missing". FBI Special Agent Jack Stanwick is handed the case. Realizing he'll have to go outside the brethren, Jack marshals the help of an old friend, Raymond Davenport, who hung a sign on a renovated brownstone in Washington, DC, with the verbiage: Davenport Detective Agency. To assist him, he hired three former police officers from various precincts and varying backgrounds, who, like himself, blew the whistle on dirty cops only to deal with the fervent hostility from the brotherhood.

With the investigation under way, the detectives stumble upon a group of men known as M.A.G.O.C., who're muddled in a governmental conspiracy involving a top-ranking official at the White House. With their many resources, they dig further and unearth Prescott Chemicals. Years earlier, the owner and his lead chemist had stolen an elixir from the Mayapo natives of the Amazon rainforest and have transformed it into a formula to be used in a congressional scheme. When the detectives accidently come into contact with the new formulation, something undesirable happens to one of them, altering his life forever.