At the center of Home Again is Madelaine - a brilliant cardiologist, a loving mother, a tender friend, and a woman full of self-doubt. It is also the story of her confused and angry daughter, Lina, and of the two very different men Madelaine loves: Francis, a priest searching for his faith, and Angel, a talented but cynical man with a broken heart. When tragedy suddenly brings them all together, they must learn to forgive the betrayals of the past and find the courage to love again.

Thirty-four-year-old Ruby Bridge is a not-too-successful comedienne who uses her mother, a nationally-syndicated "moral and spiritual counselor" as the main fodder for her cynical, rather bitter humor. Her mother Nora, long divorced from Ruby's father, is a woman whose past is just about to catch up with her - in the form of blackmail by a former lover.

Years of trying unsuccessfully to conceive a child have broken more than Angie DeSaria’s heart. Following a painful divorce, she moves back to her small Pacific Northwest hometown and takes over management of her family’s restaurant. In West End, where life rises and falls like the tides, Angie’s fortunes will drastically change yet again when she meets and befriends a troubled young woman.

Elizabeth and Jackson Shore married young, raised two daughters, and weathered the storms of youth as they built a future together. But after the children leave home, they quietly drift apart. When Jack accepts a wonderful new job offer, Elizabeth puts her needs aside to follow him across the country. Until the sudden death of her father changes everything.

The Grey sisters had only each other when their mother died years ago. Their father provided for them physically on Water's Edge, the ranch that had been in their family for three generations, each of them however, longed for their father's love.

On the day her daughter leaves for college, Anne Colwater's husband of 20 years announces he wants a divorce. Her roles of wife and mother suddenly gone, Annie retreats to her childhood home of Mystic, Washington, to heal. There she finds her old friend Nick, suddenly widowed and unable to cope with his emotionally scarred young daughter, Izzie.

In the rugged Pacific Northwest lies the Olympic National Forest - nearly a million acres of impenetrable darkness and impossible beauty. From deep within this old growth forest, a six-year-old girl appears. Speechless and alone, she offers no clue as to her identity, no hint of her past.

Meghann Dontess is a woman haunted by heartbreak. Twenty-five years ago she was forced to make a terrible choice, one that cost her everything, including the love of her sister, Claire. Now, Meghann is a hotshot divorce attorney who doesn’t believe in intimacy - until she meets the one man who can change her mind.

Meredith and Nina Whitson are as different as sisters can be. One stayed at home to raise her children and manage the family apple orchard; the other followed a dream and traveled the world to become a famous photojournalist. But when their beloved father falls ill, Meredith and Nina find themselves together again, standing alongside their cold, disapproving mother, Anya, who even now, offers no comfort to her daughters.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.

When an impossibly shy young woman named Judy Morgan finishes her studies in Physics at Cambridge University, it is with dreams of changing the world for the better. Meanwhile, a beautiful, young Jewish woman decides to flee her beloved Austria, changing her name to Hedy Lamarr, and risking everything to get to America, as far away from the Nazi threat as possible.

Texas, 1921. A time of abundance. The Great War is over, the bounty of the land is plentiful, and America is on the brink of a new and optimistic era. But for Elsa Wolcott, deemed too old to marry in a time when marriage is a woman’s only option, the future seems bleak. Until the night she meets Rafe Martinelli. By 1934, the world has changed; millions are out of work and drought has devastated the Great Plains. Elsa must make an agonizing choice: fight for the land she loves or leave it behind and go west, to California, in search of a better life for her family.

Paris, 1939: Young mothers Elise and Juliette become fast friends the day they meet in the beautiful Bois de Boulogne. Though there is a shadow of war creeping across Europe, neither woman suspects that their lives are about to irrevocably change. When Elise becomes a target of the German occupation, she entrusts Juliette with the most precious thing in her life—her young daughter, playmate to Juliette’s own little girl.

Following the unexpected death of her father, eighteen-year-old Layken becomes the rock for both her mother and younger brother. She appears resilient and tenacious, but inside, she's losing hope. Then she meets her new neighbor Will, a handsome twenty-one-year-old whose mere presence leaves her flustered and whose passion for poetry slams thrills her. Not long after a heart-stopping first date during which each recognizes something profound and familiar in the other, they are slammed to the core when a shocking discovery brings their new relationship to a sudden halt.

In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.