Erectile dysfunction is more than a bedroom issue—it’s often the first visible sign of systemic vascular trouble. In this fast-paced conversation, Dr. Nathan Bryan and Mark Young unpack how nitric oxide (NO) drives endothelial health, blood flow, and sexual function—and why PDE5 inhibitors (Viagra, Cialis) don’t work for many men unless the upstream NO pathway is working.

If you (or a partner) are dealing with ED, hypertension, or low energy, this episode explains the root cause model: restore endothelial function and nitric oxide bioavailability, then everything downstream—circulation, exercise capacity, sexual performance—has a chance to improve.

What you’ll learn

• Why ED often precedes cardiovascular disease by years (the “canary in the coal mine” effect).
• How the endothelium regulates vessel dilation and blood pressure—and how NO (the 1998 Nobel Prize molecule) keeps that system responsive.
• The exact NO → cGMP → smooth-muscle relaxation pathway (and why PDE5s need NO to work).
• Why a significant slice of men don’t respond to PDE5 drugs—and what that suggests about NO deficiency and endothelial dysfunction.
• Practical levers that influence NO biology (diet/lifestyle, oral microbiome choices, training)—and how to think about “root cause” vs. symptom-chasing.

If this episode opened your eyes to how important nitric oxide is, don’t stop here: Watch more from Dr. Nathan S. Bryan - https://www.youtube.com/@DrNathanSBryanNitricOxide Visit N101.com to explore their nitric-oxide –supporting products and educational resources - https://n1o1.com/

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