It's June in Montreal, and Dr. Temperance Brennan, who has left a shaky marriage back home in North Carolina to take on the challenging assignment of Director of Forensic Anthropology for the province of Quebec, looks forward to a relaxing weekend in beautiful Quebec City. First, though, she must stop at a newly uncovered burial site in the heart of the city. The remains are probably old and only of archeological interest, but Tempe must make sure they're not a case for the police. One look at the decomposed and decapitated corpse, stored neatly in plastic bags, tells her she'll spend the weekend in the crime lab.

Relentless phone calls interrupt the peace of a warm August morning in Three Pines. Though the tiny Québec village is impossible to find on any map, someone has managed to track down Armand Gamache, head of homicide at the Sûreté, as he sits with his wife in their back garden. Reine-Marie watches with increasing unease as her husband refuses to pick up, though he clearly knows who is on the other end. When he finally answers, his rage shatters the calm of their quiet Sunday morning.

Assaulted by the bitter cold of a Montreal winter, the American-born Dr. Temperance Breman, Forensic Anthropologist for the Province of Quebec, digs for a corpse where Sister Elisabeth Nicolet, dead over a century and now a candidate for sainthood, should lie in her grave. A strange, small coffin, buried in the recesses of a decaying church, holds the first clue to the cloistered nun's fate.

One look at the decomposed and decapitated corpse, stored neatly in plastic bags, tells Temperance Brennan she'll spend the weekend in the crime lab. Something about the crime scene is familiar to Tempe: the stashing of the body parts; the meticulous dismemberment. As a pattern continues to emerge, Tempe calls upon all her forensic skills, including bone, tooth/dental, and bite mark analysis and x-ray microflourescence to convince the police that the cases are related and to try to stop the killer before he strikes again.

He slips into their homes at night and walks silently into bedrooms where women lie sleeping, unaware of the horrors they soon will endure. The precision of the killer's methods suggests he is a deranged man of medicine, propelling the Boston newspapers and the frightened public to name him "The Surgeon". The cops' only clue rests with another surgeon, the victim of a nearly identical crime. Two years ago, Dr. Catherine Cordell fought back and killed her attacker before he could complete his assault.