Texas, 1921. A time of abundance. The Great War is over, the bounty of the land is plentiful, and America is on the brink of a new and optimistic era. But for Elsa Wolcott, deemed too old to marry in a time when marriage is a woman’s only option, the future seems bleak. Until the night she meets Rafe Martinelli. By 1934, the world has changed; millions are out of work and drought has devastated the Great Plains. Elsa must make an agonizing choice: fight for the land she loves or leave it behind and go west, to California, in search of a better life for her family.

On the day her daughter leaves for college, Anne Colwater's husband of 20 years announces he wants a divorce. Her roles of wife and mother suddenly gone, Annie retreats to her childhood home of Mystic, Washington, to heal. There she finds her old friend Nick, suddenly widowed and unable to cope with his emotionally scarred young daughter, Izzie.

Like many couples, Michael and Jolene Zarkades have to face the pressures of everyday life—children, careers, bills, chores—even as their twelve-year marriage is falling apart. Then a deployment sends Jolene deep into harm's way and leaves defense attorney Michael at home, unaccustomed to being a single parent to their two girls. As a mother, it agonizes Jolene to leave her family, but as a solider, she has always understood the true meaning of duty. In her letters home, she paints a rose-colored version of her life on the front lines, shielding her family from the truth.

The Grey sisters had only each other when their mother died years ago. Their father provided for them physically on Water's Edge, the ranch that had been in their family for three generations, each of them however, longed for their father's love.

In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

Meredith and Nina Whitson are as different as sisters can be. One stayed at home to raise her children and manage the family apple orchard; the other followed a dream and traveled the world to become a famous photojournalist. But when their beloved father falls ill, Meredith and Nina find themselves together again, standing alongside their cold, disapproving mother, Anya, who even now, offers no comfort to her daughters.

Thirty-four-year-old Ruby Bridge is a not-too-successful comedienne who uses her mother, a nationally-syndicated "moral and spiritual counselor" as the main fodder for her cynical, rather bitter humor. Her mother Nora, long divorced from Ruby's father, is a woman whose past is just about to catch up with her - in the form of blackmail by a former lover.

Elizabeth and Jackson Shore married young, raised two daughters, and weathered the storms of youth as they built a future together. But after the children leave home, they quietly drift apart. When Jack accepts a wonderful new job offer, Elizabeth puts her needs aside to follow him across the country. Until the sudden death of her father changes everything.

In the rugged Pacific Northwest lies the Olympic National Forest - nearly a million acres of impenetrable darkness and impossible beauty. From deep within this old growth forest, a six-year-old girl appears. Speechless and alone, she offers no clue as to her identity, no hint of her past.

Michaela, beloved wife and mother of two, lies in a coma. Doctors have told her husband Liam not to expect a recovery, but he maintains hope that love can accomplish what medicine cannot. Day after day, he sits by her bedside, holding her hand, sharing the stories of their life together. Then he discovers the evidence of his wife's secret past - a long hidden first marriage to international movie star Julian True.