Six years after the fight that ended their friendship, Daphne Berg is shocked when Drue Cavanaugh walks back into her life, looking as lovely and successful as ever, with a massive favor to ask. Daphne hasn’t spoken one word to Drue in all this time - she doesn’t even hate-follow her ex-best friend on social media - so when Drue asks if she will be her maid-of-honor at the society wedding of the summer, Daphne is rightfully speechless.

Addie Downs and Valerie Adler will be best friends forever. That’s what Addie believes after Valerie moves across the street when they’re both nine years old. But in their teenage years, Val is swept into the popular crowd. Flash-forward 15 years. Addie Downs lives alone in her parents’ house, caring for a troubled brother and trying to meet Prince Charming on the Internet. she opens her door to find her long-gone best friend standing there, a terrified look on her face and blood on the sleeve of her coat.

Cannie Shapiro never wanted to be famous. The smart, sharp, plus-sized pop culture reporter was perfectly content writitng about other people's lives in the pages of the Philadlphia Examiner. But the day she opened up a national women's magazine to find out that her ex-boyfriend has been chronicling their ex-sex life is the day her life changes forever.

Daisy Shoemaker can’t sleep. With a thriving cooking business, full schedule of volunteer work, and a beautiful home in the Philadelphia suburbs, she should be content. But her teenage daughter can be a handful, her husband can be distant, her work can feel trivial, and she has lots of acquaintances, but no real friends. Still, Daisy knows she’s got it good. So why is she up all night?

It’s 2 AM on a Saturday night in the spring of 2001, and 28-year-old Cecily Gardner sits alone in a dive bar in New York’s East Village, questioning her life. Feeling lonesome and homesick for the Midwest, she wonders if she’ll ever make it as a reporter in the big city - and whether she made a terrible mistake in breaking up with her longtime boyfriend, Matthew. 

It’s been almost two years since Effie’s beloved parents got divorced, destroying the image of the happy, loving childhood she thought she had. Since then, she’s become estranged from her father and embarked on a feud with his hot (and much younger) girlfriend, Krista. And now, more earth-shattering news: They’ve sold Greenoaks, the rambling Victorian country house Effie has always called home.

At 23, Ruth Saunders headed west with her 70-year-old grandma in tow, hoping to be hired as a television writer. Four years later, she's hit the jackpot when she gets The Call: the sitcom she wrote, The Next Big Thing, has gotten the green light, and Ruthie's going to be the show-runner. But her dreams of Hollywood happiness are threatened by demanding actors, number-crunching executives, an unrequited crush on a boss, and her grandmother's impending nuptials.

Jules Strauss is a Princeton senior with a full scholarship, acquaintances instead of friends, and a family she's ashamed to invite to Parents' Weekend. With the income she'll receive from donating her "pedigree" eggs, she believes she can save her father from addiction.

New York socialite Caroline Ferriday has her hands full with her post at the French consulate and a new love on the horizon. But Caroline's world is forever changed when Hitler's army invades Poland in September 1939 - and then sets its sights on France. An ocean away from Caroline, Kasia Kuzmerick, a Polish teenager, senses her carefree youth disappearing as she is drawn deeper into her role as courier for the underground resistance movement.

Nina Browning is living the good life after marrying into Nashville's elite. More recently, her husband made a fortune selling his tech business, and their adored son has been accepted to Princeton. Yet sometimes the middle-class small-town girl in Nina wonders if she's strayed from the person she once was. Tom Volpe is a single dad working multiple jobs while struggling to raise his headstrong daughter, Lyla. His road has been lonely, long, and hard, but he finally starts to relax after Lyla earns a scholarship to Windsor Academy, Nashville's most prestigious private school.