What do you do when your carefully planned life takes a wrong turn into hell? When Quinn Maguire, a dashing young trauma surgeon, unaccountably accepts a position as an ER physician, her new boss, Honor Blake, suspects that Quinn is hiding a dark secret. While the two declare an uneasy truce in an effort to work together, both struggle with mutual, and unexpected, attraction.

Ren Dunbar is used to never fitting in—anywhere. Graduating high school at 13 and med school at 19 pretty much guaranteed she’d always have trouble proving she belonged, but she’s okay with that. She prefers the solitude of the lab over the raucous atmosphere in the OR, which would be fine except she’s a surgery resident. Winning the Benjamin Franklin Prize in surgery is just the proof she needs to show everyone she deserves to be part of their world. 

Homicide detective Tori Hunter was used to doing things her way. But even after six different partners in seven years, she was not prepared for the hot-tempered Samantha Kennedy. Samantha, on the other hand, was trying to juggle a new job and a demanding boyfriend and now finds herself with an even greater challenge - being partnered with the most difficult detective in the entire squad.

Michael Lassiter, a theoretical design executive, is about to wage war on the corporate battlefield as she fights to maintain control of her company in the midst of divorce. She hires JT Sloan, an Internet security consultant, to protect her most important asset - her dreams and visions, which are suddenly vulnerable within the corporate computer system. Sloan, a brilliant cybersleuth who steadfastly avoids emotional commitments, shares a painful, secret past with her associate and friend, Jason McBride.

Zoey Cohen spent a lifetime learning to hide disappointment and loss behind a mask of unshakeable calm and control, even when her longtime friend-with-benefits lover moves on for true love. Declan Black returns to Philadelphia Medical Center after an accident costs her the life she’d built and her career. Zoey will never accept second place in matters of the heart, even when her rival is a career, and Dec has nothing left to give. Sometimes change is a force more powerful than will.