Jason Bennett is a suburban dad who owns a court-reporting business, but one night, his life takes a horrific turn. He is driving his family home after his daughter’s field hockey game when a pickup truck begins tailgating them, on a dark stretch of road. Suddenly two men jump from the pickup and pull guns on Jason, demanding the car. A horrific flash of violence changes his life forever.

Dr. Noah Alderman, a widower and single father, has remarried a wonderful woman, Maggie Ippolitti, and for the first time in a long time, he and his young son are happy. Despite her longing for the daughter she hasn’t seen since she was a baby, Maggie is happy too, and she’s even more overjoyed when she unexpectedly gets another chance to be a mother to the child she thought she'd lost forever, her only daughter Anna.

When reporter Ellen Gleeson gets a "Have You Seen This Child?" flyer in the mail, she almost throws it away. But something about it makes her look again, and her heart stops—the child in the photo is identical to her adopted son, Will. Her every instinct tells her to deny the similarity between the boys, because she knows her adoption was lawful. But she's a journalist and won't be able to stop thinking about the photo until she figures out the truth. And she can't shake the question: if Will rightfully belongs to someone else, should she keep him or give him up?

TJ Devlin is the charming disappointment in the prominent Devlin family, all of whom are lawyers at their highly successful firm—except him. After a stint in prison and rehab for alcoholism, TJ can’t get hired anywhere except at the firm, in a make-work job with the title of investigator. But one night, TJ’s world turns upside down after his older brother John confesses that he murdered one of their clients, an accountant he’d confronted with proof of embezzlement. It seems impossible coming from John, the firstborn son and Most Valuable Devlin.

They’re one of the country’s most telegenic couples: beloved TV journalist Sara Lowell and New York’s hottest basketball star, Michael Silverman. Their family and social connections tie them to the highest echelons of the political, medical, and sports worlds - threads that will tangle them up in one of the most controversial and deadly issues of our time. In a clinic on Manhattan’s Upper West Side, a doctor has dedicated his life to eradicating a divisive and devastating disease. One by one, his patients are getting well.

For 12-year-old Cora Landry and her friends Violet and Jordyn, it was supposed to be an ordinary sleepover - movies and Ouija and talking about boys. But when they decide to sneak out to go to the abandoned rail yard on the outskirts of town, little do they know that their innocent games will have dangerous consequences. Later that night, Cora Landry is discovered on the tracks, bloody and clinging to life, her friends nowhere to be found. Soon, their small rural town is thrust into a maelstrom. Who would want to hurt a young girl like Cora - and why?

Franco Fiorvanti is a handsome lemon grower toiling on the estate of a baron. He dreams of owning his own grove, but the rigid class system of Sicily thwarts his ambition. Determined to secure a better future, Franco will do anything to prove his loyalty to the baron. But when the baron asks him to kidnap a little boy named Dante, Franco makes a decision that will change his life—and even the history of Sicily—forever.

Victoria Barnett has it all: a great career as a nurse practitioner, a handsome and loving husband, a beautiful home in the suburbs, and a plan to fill it with children. Life is perfect—or so it seems. Then she’s in a terrible accident...and everything falls apart. Now Victoria is unable to walk. She can’t feed or dress herself. She can’t even speak. She is confined to the top floor of her house with 24-hour care.

On paper, Chris Brennan looks perfect. He's applying for a job as a high school government teacher, he's ready to step in as an assistant baseball coach, and his references are impeccable. But everything about Chris Brennan is a lie. Susan Sematov is proud of her son Raz, a high school pitcher so athletically talented that he's being recruited for a full-ride scholarship to a Division I college, with a future in major-league baseball. But Raz’s father died only a few months ago, leaving her son in a vulnerable place where any new father figure might influence him for good, or evil.

Rose McKenna volunteers as a lunch mom in her daughter Melly's school in order to keep an eye on Amanda, a mean girl who's been bullying her daughter. Her fears come true when the bullying begins, sending Melly to the bathroom in tears. Just as Rose is about to follow after her daughter, a massive explosion goes off in the kitchen, sending the room into chaos. Rose finds herself faced with the horrifying decision of whether or not to run to the bathroom to rescue her daughter or usher Amanda to safety.

Tory Bodeen grew up in a run-down house where her father ruled with an iron fist and a leather belt - and where her dreams and talents had no room to flourish. Her one escape was her neighbor Hope, who lived in the big house just a short skip away, and whose friendship allowed Tory to be something she wasn’t allowed to be at home: a child. Then Hope was brutally murdered, and everything fell apart.

Elisabetta, Marco, and Sandro grow up as the best of friends despite their differences. Elisabetta is a feisty beauty who dreams of becoming a novelist; Marco the brash and athletic son in a family of professional cyclists; and Sandro a Jewish mathematics prodigy, kind-hearted and thoughtful, the son of a lawyer and a doctor. Their friendship blossoms to love, with both Sandro and Marco hoping to win Elisabetta's heart.

Ava only left her daughter in the pushchair for five minutes. The buckle was fastened, and she was sure it was safe. But when she came downstairs, the door was open and Abi was gone - she walked down the road, past the Lovegoods' house, and was never seen again. A year later, the Lovegoods throw a housewarming party, showing off the results of their renovation. Ava doesn’t want to go. She can’t bear to look down that end of the road, to see the place where Abi vanished, and she doesn’t want to spend time with people who don’t share her grief. 

Kelsey Byden always believed that her mother was dead. But now, after all this time, she has discovered the truth: Naomi Chadwick is still alive - after spending years in prison for the murder of her lover. Now, at Naomi’s Virginia horse farm, Kelsey is trying to sort out a lifetime of deception - and her feelings about her mother. The bonds of love can be fragile...as Kelsey learned from her recently ended marriage.

Dr. Eric Parrish is the chief of the psychiatric unit at Havemeyer General Hospital outside of Philadelphia. Recently separated from his wife, Alice, he is doing his best as a single dad to his seven-year-old daughter, Hannah. His work seems to be going better than his homelife, however. His unit at the hospital has just been named number two in the country and, Eric has a devoted staff of doctors and nurses who are as caring as he is. But when he takes on a new patient, Eric's entire world begins to crumble.