The city of Miami is Detective Tom Moon's backyard. He's always kept it local, attending University of Miami on a football scholarship, and, as a Miami PD officer, protecting the city's most vulnerable. Now, as the new leader of an FBI task force called "Operation Guardian", it's his mission to combat international crime. Moon's investigative team discovers that the opportunistic "Blood Brothers" - Russian nationals Roman and Emile Rostoff - have evaded authorities while building a vast, powerful, and deadly crime syndicate throughout Europe and metropolitan Miami.

The Inn at Gloucester stands alone on the rocky shoreline. Its seclusion suits former Boston police detective Bill Robinson, novice owner and innkeeper. As long as the dozen residents pay their rent, Robinson doesn't ask any questions. Neither does Sheriff Clayton Spears, who lives on the second floor. Then Mitchell Cline arrives, with a deadly new way of doing business. His crew of local killers break laws, deal drugs, and bring violence to the doors of the Inn. 

When New York City's Mayor is desperate to find his missing daughter, Detective Michael Bennett steps in to help the Mayor and strike a deal to save his son in prison. Bennett and the mayor have always had a tense relationship, but now the mayor sees in Bennett a discreet investigator with family worries of his own. Just one father helping another. The detective leaps into the case and sources lead him to a homicide in the Bronx. The victim has ties to a sophisticated hacking operation - and also to the mayor's missing daughter, Natalie, a 21-year-old computer prodigy.  

FBI Agent Emmy Dockery is absolutely relentless. She's young and driven, and her unique skill at seeing connections others miss has brought her an impressive string of arrests. But a shocking new case - unfolding across the country - has left her utterly baffled. The victims all appear to have died by accident, and have seemingly nothing in common. But this many deaths can't be coincidence. And the killer is somehow one step ahead of every move Dockery makes. How? To FBI Special Agent Harrison "Books" Bookman, everyone in the FBI is a suspect - particularly Emmy Dockery.

Prison is a dangerous place for a former cop - as Harriet Blue is learning on a daily basis. So, following a fight for her life and a prison-wide lockdown, the last person she wants to see is Deputy Police Commissioner Joe Woods. The man who put her inside. But Woods is not there to gloat. His daughter Tonya and her two-year-old child have gone missing. He's ready to offer Harriet a deal: find his family to buy her freedom....

Detective Harriet Blue is a very good cop...gone very bad. In the space of a week, she has committed theft and fraud, resisted arrest, assaulted a police officer, and is considered a dangerous fugitive from the law. It's all because of one man: Regan Banks. He viciously killed the only person in the world who matters to Harriet - and he plans to kill her next. As she recklessly speeds toward the dark side - and finally crosses it - Harriet won't stop until Regan pays for the many lives he has taken.  

Once a luxurious Southern getaway on a rustic lake, then reduced to a dilapidated crash pad, the Summer House is now the grisly scene of a nighttime mass murder. Eyewitnesses point to four Army Rangers - known as the Night Ninjas - recently returned from Afghanistan. To ensure that justice is done, the Army sends Major Jeremiah Cook, a veteran and former NYPD cop, to investigate. But the major and his elite team arrive in sweltering Georgia with no idea their grim jobs will be made exponentially more challenging by local law enforcement....

In a Virginia penitentiary, Alex Cross and his partner, John Sampson, witness the execution of a killer they helped convict. Hours later, they are called to the scene of a copycat crime. A note signed "M" rests on the corpse. "You messed up big time, Dr. Cross." Was an innocent man just put to death? Alex soon realizes he may have much to answer for, as "M" lures the detective out of the capital to the sites of multiple homicides, all marked with distressingly familiar details - details that conjure up decades-old cases.

Reality star Erin Easton's "Wedding of the Century" may have a cable crew documenting every extravagant bridal detail, but when "Airhead Easton" disappears from the reception, it's no diva turn. Her dressing room is empty but for a blood-spattered wedding gown and signs of a struggle. Detective Kylie MacDonald of NYPD Red, already on-scene as a plus-one, loops in her partner to activate level one mobilization for this PR nightmare. But when Erin's "proof of life" video makes it to air, every A-lister on the guest list becomes a target of suspicion, or just a target.

To Senior Midwife Lucy Ryuan, pregnancy is not an unusual condition, it's her life's work. But when two kidnappings and a vicious stabbing happen on her watch in a university hospital in Manhattan, her focus abruptly changes. Something has to be done, and Lucy is fearless enough to try. Rumors begin to swirl, blaming everyone from the Russian Mafia to an underground adoption network. The feisty single mom teams up with a skeptical NYPD detective to solve the case, but the truth is far more twisted than Lucy could ever have imagined.

Former SAS soldier David Shelley was part of the most covert operations team in the special forces. Now settling down to civilian life in London, he has plans for a safer and more stable existence. But the shocking death of a young woman Shelley once helped protect puts those plans on hold. The police rule the death a suicide but the grieving parents can't accept their beloved Emma would take her own life. They need to find out what really happened, and they turn to their former bodyguard, Shelley, for help.

Angela's graduate school days at MIT come to an abrupt end when she uses her hacking skills on another student's computer. Yet her mentor, Eve Abajian, arranges a new beginning for her - as an intern in FBI's Boston field office. Her new supervisor, Assistant Special Agent in Charge William Keats, one of only two agents in the Northeast to make his rank before the age of 30, sees in Angela a fellow prodigy. But Angela's skills come with a natural curiosity, which is also a dangerous liability. 

In Los Angeles, Detective Garrett Dobbs and FBI Agent Jessica Gimble have joined forces to work a murder that seems like a dead cinch. Their chief suspect is quickly identified and apprehended - but then there's another killing just like the one they've been investigating. And another. And not just in Los Angeles - the spree spreads across the country. The Fitzgerald family comes to the investigators' attention, but Dobbs and Gimble are at a loss - if one of the four is involved, which Fitzgerald might it be?

Kay Willingham led a life as glamorous as it was public - she was a gorgeous Georgetown socialite, philanthropist, and the ex-wife of the vice president. So why was she parked in a Bentley convertible idling behind a DC private school, in the middle of the night, with the man who was the head of that school? Who shot them both, point blank, and why? The shocking double homicide is blazed across the internet, TV, newspapers - and across Alex Cross's mind. Kay had been his patient once. And maybe more.

Clay Edison has his hands full. He’s got a new baby who won't sleep. He’s working the graveyard shift. And he’s trying, for once, to mind his own business. Then comes the first call. Workers demolishing a local park have made a haunting discovery: the decades-old skeleton of a child. But whose? And how did it get there? No sooner has Clay begun to investigate than he receives a second call - this one from a local businessman, wondering if the body could belong to his sister.