By the bestselling author of Astoria, a thrilling and masterfully crafted narrative of the Conquistador Francisco Coronado’s expedition across 2,500 miles of the vast uncharted North American interior—“El Norte Misterioso” —where he was turned back by fierce indigenous resistance that would thwart white rule for the next three hundred years.

In 1540, the grandest exploring expedition ever assembled in the Americas paraded north from the ruins of the Aztec capital Tenochtitlan, a glittering column of 2,000 men heading into the unknown. Their destination was El Norte Misterioso—The Mysterious North, present-day United States—where fabulous cities of gold were rumored to shine beyond the horizon. Two years later, survivors began stumbling back, half dead. Lost to poisoned arrows, brutal deserts, starvation, cold, desertion, and countless other hardships, 90% of those who left would never return.

Led by Francisco Coronado and backed by the full weight of the Spanish empire, the superpower of its day, they had expected to seize the land, steal its riches, and subjugate its peoples, just as they had so recently done to the mighty Aztec and Inca empires. But instead they encountered the unconquered American West, populated by complex societies of indigenous nations, masters of a vast and unforgiving landscape who fiercely resisted this European “incursion” onto their lands.

Coronado and his people traversed 2,500 miles of unmapped terrain, ranging across the present-day U.S. states of California, Arizona, New Mexico, Texas, Oklahoma, and finally Kansas. They were the first Europeans to gaze upon the Grand Canyon and the Rocky Mountains; made first contact with the Puebloan peoples; crossed the Sonoran Desert and the Great Plains, where they encountered endless herds of bison and the nomadic tribes who followed them. After leading the largest exploring cavalcade ever assembled in the New World, wearing his gilded armor and bobbing plume, Coronado retreated back to Mexico City two years later accompanied only by a hundred or so hangers-on and carried on a litter, a broken man. America’s Southwest and Plains would remain unconquered for the next 300 years.