Rudolf Sebestyen is missing, and Marianne Smalls is involved in an illicit affair with the shady Jonas Schmitt. Both cases converge when Dora Urban, Rudolf's beautiful and mysterious half-sister, and Lamont Smalls, Marianne's suspicious husband, hire Jack Mitchell, a hard-drinking, chain-smoking private investigator. Dora wants Jack to uncover what happened to her brother, while Lamont seeks proof of his wife's infidelity. But Dora is a vampire, in a city teeming with creatures of the night.

As Jack dives deeper, he discovers that both cases are linked to vepratoga—a dangerous new drug spreading through Los Angeles. Twice as Dead is brimming with vampires, wizards, zombies and zombie dealers, the Central Avenue jazz scene, an exclusive after-hours club, adultery, a New England ghost who prefers Southern California's warmer clime, corrupt cops and politicians, spying rats, and a smart-mouthed talking cat.

When Jack's home is burned to the ground, the strands of his investigations culminate in a showdown at a tire factory, where even the reliefs on the walls are not what they seem. In this unique noirish urban fantasy set in postwar Los Angeles, Jack finds more adventure, danger, and romance than he ever imagined—and learns that success may come at too high a price.