John Perry did two things on his 75th birthday. First he visited his wife's grave. Then he joined the army. The good news is that humanity finally made it into interstellar space. The bad news is that planets fit to live on are scarce—and alien races willing to fight us for them are common. So: we fight. To defend Earth, and to stake our own claim to planetary real estate. Far from Earth, the war has been going on for decades: brutal, bloody, unyielding. Earth itself is a backwater.

Our universe is ruled by physics, and faster-than-light travel is not possible - until the discovery of The Flow, an extradimensional field we can access at certain points in space-time that transports us to other worlds, around other stars. Humanity flows away from Earth, into space, and in time forgets our home world and creates a new empire, the Interdependency, whose ethos requires that no one human outpost can survive without the others. It's a hedge against interstellar war - and a system of control for the rulers of the empire.

In a corporate-dominated spacefaring future, planetary missions must be approved and supplied by the Company. Exploratory teams are accompanied by Company-supplied security androids, for their own safety. But in a society where contracts are awarded to the lowest bidder, safety isn’t a primary concern. On a distant planet, a team of scientists are conducting surface tests, shadowed by their Company-supplied ‘droid—a self-aware SecUnit that has hacked its own governor module, and refers to itself (though never out loud) as “Murderbot.”

The Galahad, a faster-than-light spacecraft, carries 50 scientists and engineers on a mission to prepare Kepler 452b, Earth's nearest habitable neighbor at 1400 light years away. With Earth no longer habitable and the Mars colony slowly failing, they are humanity's best hope. After 10 years in a failed cryogenic bed - body asleep, mind awake - William Chanokh's torture comes to an end as the fog clears, the hatch opens, and his friend and fellow hacker, Tom, greets him...by stabbing a screwdriver into his heart. This is the first time William dies.

Not too long from today, a new, highly contagious virus makes its way across the globe. Most who get sick experience nothing worse than flu, fever, and headaches. But for the unlucky one percent - and nearly five million souls in the United States alone - the disease causes "Lock In": Victims fully awake and aware, but unable to move or respond to stimulus. The disease affects young, old, rich, poor, people of every color and creed. The world changes to meet the challenge.