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Breast cancer screening may be on the verge of a major shift—from one-size-fits-all mammograms to personalized screening based on individual risk. The best news is that a custom program led to fewer tests, less radiation exposure, but no increased risk of missing a treatable cancer.

UC San Francisco surgical oncologists led a multicenter collaborative study of 46,000 women 40 to 74 years of age and report their results in the journal JAMA Network. Half that number received personalized screening while the other half, the control group, received annual screening mammography.

The custom treatment cohort was divided to 4 groups based on their risk of developing breast cancer as assessed by genetic screening, family history, and other factors. The highest risk women received 6 monthly screening with alternating conventional mammography and MR imaging as well as risk reduction counseling. The elevated risk group received annual mammography and counseling. The average risk group received mammography every 2 years. The low risk group, the youngest women with minimal risk factors, received no screening until age 50 or the advent of a risk increase.

The result. Risk-based screening is safe and effective. It diminished the numbers of mammograms performed. It did not reduce the numbers of breast biopsies. The personalized approach is popular with 89% of the participants indicating that they preferred it.

https://www.sciencedaily.com/releases/2026/01/260103155036.htm

https://jamanetwork.com/journals/jama/article-abstract/2842903

#breast #cancer #screening #genetics #biopsy