We’re tackling your questions about midlife hormone support. We’ll debunk common myths, unpack the research, and break down the basics of hormone support. We’ll also discuss some of the systemic benefits that may come with taking hormones, as well as important considerations for people with a history of health conditions, like cancer or stroke. Joining Dr. Elizabeth Poynor for this discussion is Atria Health Institute’s Chief Content Officer Siobhan O’Connor.

Links to resources mentioned in this episode:

(00:25:29) - Decoding Happiness in Midlife with Dr. Laurie Santos

(00:27:27) - Decoding Brain Fog with Dr. Caroline Gurvich

(00:48:00) - Decoding Partnership in Midlife with Dr. Richard Shapiro

Vaginal estrogen use in breast cancer survivors: a systematic review and meta-analysis of recurrence and mortality risks

Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial

Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer’s disease and dementia

Menopausal Hormone Therapy and Risk of Endometrial Cancer

Allopregnanolone and Reproductive Psychiatry: An Overview

Adverse Changes in Body Composition During the Menopausal Transition and Relation to Cardiovascular Risk: A Contemporary Review

The role of lifestyle medicine in menopausal health: a review of non-pharmacologic interventions

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

ADHD and Sex Hormones in Females: A Systematic Review

The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study

The use of HRT containing transdermal estradiol in women with a personal history of venous or arterial thromboembolism: A consecutive series of 115 cases

Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2025)

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

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