Welcome to the September 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2025 issue of Diabetes.

5:25 In the first segment, our hosts are joined by Carmelo Quarta, PhD, a principal investigator at INSERM (National Institute of Health and Medical Research) and a group leader at the Bordeaux Neurocampus at the University of Bordeaux in France. He is the co-corresponding author of “GLP-1–Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice,” available for free at doi.org/10.2337/db24-1071.

27:30 Next, Darleen and Kirk speak with Willa A. Hsueh, MD, Professor of Medicine in the Division of Endocrinology at the Ohio State University College of Medicine. She is a corresponding author on this month’s Paper of the Month, “The GLP-1 Receptor Agonist Dulaglutide Attenuates Hepatic Steatosis in Obesity via a Weight-Independent Mechanism,” available for free at doi.org/10.2337/db24-0861.

46:20 Lastly, in this month’s edition of “Sweet Talk,” Kevin and Darleen are joined by Alexander R. Nectow, MD, PhD. A recipient of the American Diabetes Association’s Pathway to Stop Diabetes Award, Dr. Nectow lab at Columbia University studies the dorsal raphe nucleus (DRN) and its relation to metabolism. His article, "The Dorsal Raphe Nucleus and the Integrative Control of Feeding: A Report on Research Supported by Pathway to Stop Diabetes,” is available for free at doi.org/10.2337/dbi24-0015.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

In this special crossover episode, recorded live at the American Diabetes Association’s 85th Scientific Sessions in Chicago, the hosts of ADA’s professional podcasts—Diabetes Core Update, Diabetes Care “On Air”, and DiabetesBio—come together to discuss key highlights and groundbreaking research presented at the 2025 meeting.

They share expert insights across the bench-to-bedside spectrum, including basic science, clinical research, and the latest in diabetes care and education. Tune in for thoughtful reflections on what this year’s findings mean for clinical practice and future research.

Available now across all ADA professional podcast channels.

Featured Podcasts:

• DiabetesBio – From ADA’s flagship research journal, Diabetes

• Diabetes Care “On Air” – From ADA’s clinical research journal, Diabetes Care

• Diabetes Core Update – ADA’s podcast for primary care

Join the Discussion with:

• Alice Cheng, MD – Co-host of Diabetes Care “On Air”

• Kirk Habegger, PhD – Co-host of DiabetesBio

• Michael Rickels, MD, MS – Co-host of Diabetes Care “On Air”

• Darleen Sandoval, PhD – Co-host of DiabetesBio

• Neil Skolnik, MD – Co-host of Diabetes Core Update and Diabetes Day by Day

• Kevin Williams, PhD – Co-host of DiabetesBio

🔗 Learn more about ADA’s full podcast portfolio:
https://diabetesjournals.org/journals/pages/podcasts

Subscribe to Diabetes Core Update, Diabetes Care “On Air”, and DiabetesBio on Apple Podcasts, Amazon Music, Spotify, or your preferred platform.

Welcome to the August 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2025 issue of Diabetes.

6:55 For this month’s episode, a special extended edition of “Sweet Talk,” exploring the debate about whether GIP receptor agonism or GIP receptor antagonism holds the most promise for therapeutic strategies. First, our hosts are joined by Daniel J. Drucker, OC, MD, FRCPC, FRSC, FRS, recipient of the American Diabetes Association’s (ADA) 2014 Banting Medal for Scienfitic Achievement for his research with GLP-1s. They also speak with Jonathan Campbell, PhD, Associate Professor in Medicine at the Duke Molecular Physiology Institute at Duke University. They discuss the history of endocrine biology research and their article, “Therapeutic Targeting of the GIP Receptor—Revisiting the Controversies,” available for free at doi.org/10.2337/db25-0393.

42:00 As the conversation continues, our guests discuss the controversy of the GIP receptor agonism, antagonism debate. These arguments are highlighted in a special debate series in the August issue of Diabetes, featuring a point article, “A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity,” available for free at ​​doi.org/10.2337/dbi24-0026, and a counterpoint article titled “GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale,” also available for free at doi.org/10.2337/dbi24-0027.

And don’t forget to reach out! Let us know your stance in the debate between agonism and antagonism, and share your favorite science-related podcasts!

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!