Professor Richard Miller of the University of Michigan, a leading expert in the biology of aging, joins us to redefine what aging is and how we can slow it down.

Discover the groundbreaking work of the Interventions Testing Program (ITP), which has identified over a dozen compounds—including the drug Rapamycin—capable of extending the healthy lifespan of mice by up to 30%. Miller reveals why this level of lifespan extension is considered ten times more effective than finding a complete cure for all adult cancers.

We dive into his revolutionary concept of "Aging Rate Indicators" (the biological "speedometer") and how this new metric is essential for filtering promising anti-aging drugs in mere months, bypassing the need for decades-long clinical trials. Learn why the search for a single "mechanism of aging" is a flawed approach and why widely popular concepts like cellular senescence and telomeres are considered scientific "zombie ideas".

If you're interested in the future of longevity and the science behind the most effective anti-aging drugs, this episode provides an unfiltered look at the cutting edge of biogerontology.

For more information, please see our website: https://www.discoveringacademia.com/episodes/richard-miller

This presentation is a service of Discovering Academia, and all information presented is for commercial and informational purposes only. Discovering Academia provides no assurances as to the accuracy or completeness of the information presented and possesses no actual knowledge of any topic presented. Any opinions expressed in this presentation are solely attributed to each individual asserting the same and do not reflect the opinion of Discovering Academia.

Steven Austad is a Distinguished Professor and the Protective Life Endowed Chair in Healthy Aging Research at the University of Alabama at Birmingham, as well as the Scientific Director of the American Federation for Aging Research. A former Hollywood lion trainer turned leading biologist, Austad explores the evolutionary and biological mechanisms that control how fast we age.

In this episode, we dive into the science of longevity — from why island opossums age slower to what birds can teach us about extending human healthspan. We also discuss why women consistently live longer than men, despite facing more health challenges in old age, and the flaws in how aging research is conducted in sterile lab environments. Finally, Austad shares insights behind his famous $100 million bet that someone alive today will live to 150.

Topics: longevity science, women’s lifespan, comparative biology, aging research, healthspan extension, evolutionary biology For more information about this episode, see our website: https://www.discoveringacademia.com/episodes/steven-austad This presentation is a service of Discovering Academia, and all information presented is for commercial and informational purposes only. Discovering Academia provides no assurances as to the accuracy or completeness of the information presented and possesses no actual knowledge of any topic presented. Any opinions expressed in this presentation are solely attributed to each individual asserting the same and do not reflect the opinion of Discovering Academia.

Ying Lu is an Assistant Professor in the Department of Systems Biology at Harvard Medical School. His work combines physics, biochemistry, and quantitative methods to understand the fundamental mechanisms of biological processes, particularly protein degradation. In this episode, we discuss why curiosity is the most powerful engine for scientific breakthroughs, from the discovery of CRISPR to modern weight-loss drugs. We explore the cell’s sophisticated quality control system, where a "barcode" tag called ubiquitin marks unwanted proteins for destruction by a nanoscale "shredder." Professor Lu explains how failures in this system are linked to diseases like Alzheimer's and cancer, and how his research could lead to new therapies that either inhibit or boost this process to restore health.

For more information about this episode, visit our website: https://www.discoveringacademia.com/episodes/ying-lu

This presentation is a service of Discovering Academia, and all information presented is for commercial and informational purposes only. Discovering Academia provides no assurances as to the accuracy or completeness of the information presented and possesses no actual knowledge of any topic presented. Any opinions expressed in this presentation are solely attributed to each individual asserting the same and do not reflect the opinion of Discovering Academia.