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What if a 5-minute test could predict—with 90% accuracy—whether a $50,000 medication will actually work for you?

In this episode, Dr. Barrett sits down with Dr. Andrew Holman, rheumatologist and CEO of Inmedix, to explore the hidden biology of stress and how it directly controls your immune system—millisecond by millisecond—through heart rate variability (HRV).

This isn't another generic "manage your stress" talk. We dive into measurable, clinical-grade HRV and how it's changing the way doctors predict treatment response in rheumatoid arthritis, autoimmune disease, and chronic pain.

In this episode, you'll learn:

➡️Why wearables like Oura Ring and Whoop don't tell the full clinical story
➡️The surprising link between sleep apnea and rheumatoid arthritis (even without snoring)
➡️How stress biologically regulates immune function in real time
➡️How an FDA-cleared HRV test measures both branches of the autonomic nervous system
➡️Why this technology could save $34 billion in healthcare costs over the next decade

The big takeaway: Stress isn't psychological—it's measurable physiology that may be sabotaging your treatment outcomes.

If you care about precision medicine, HRV, immune health, autoimmune disease, or longevity, this is a must-watch.

🔔 Subscribe for more deep dives into cutting-edge health science.

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Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
00:00 Introduction & Episode Overview
01:38 Interview Begins
03:26 What Is Heart Rate Variability (HRV)?
04:02 HRV and the Autonomic Nervous System
05:00 Why HRV Matters Clinically
06:01 Consumer Wearables vs Medical-Grade HRV
08:18 Development of Cloud HRV Technology
09:33 Technical Requirements for Accurate HRV
10:00 Inside the Cloud HRV System
11:00 Measuring Both Sympathetic & Parasympathetic Systems
11:41 Interpreting Autonomic Measurements
13:09 Why HRV Matters in Medicine
14:27 Better Tools for Measuring Stress
14:41 Mainstream Recognition of Stress Biology
16:11 Vagus Nerve Stimulation & Immune Control
16:19 Medical School vs Modern Science
20:57 Clinical Applications & Treatment Strategy
22:39 Sleep Apnea and Rheumatoid Arthritis
23:07 Sleep Heart Health Study
23:31 Japanese RA Sleep Apnea Study
24:01 Effects of Treating Sleep Apnea
25:00 Key Lessons for Rheumatologists
25:45 The Future of Autonomic Medicine
27:19 Prevention & Risk Assessment
28:12 Predicting Rheumatoid Arthritis Risk
28:58 Restoring Physiologic Balance
29:09 Adoption of HRV in Clinical Practice
30:00 Availability & Insurance Coverage
31:34 Patient Perspectives on Stress
32:27 Future of Rheumatology Practice
33:08 Patient Demand & Treatment Limits
33:23 HRV as a Missing Vital Sign
34:10 Follow-Up Testing Strategies
34:44 Predicting Biologic Drug Response
36:27 Combination Therapy Study
38:58 East Meets West Medicine
39:08 Need for Objective Measurement
39:38 Restless Leg Syndrome & Nerve Entrapment
41:39 The Phoenix Sign Explained
42:14 Importance of Diagnostics
42:52 Atypical Disease Presentations
44:37 Economic Impact of Immuno-Autonomics
46:40 Autonomics Across Medicine
48:04 Stress, Strain, and Duress
48:40 Addressing Suffering in Medicine
50:00 About InMedix
51:01 Company Timeline & Funding
51:38 InMedix Mission
52:01 Business Development & Growth
53:35 Vision for the Future
53:56 Closing Remarks

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#HRV #StressScience #AutoimmuneHealth #RheumatoidArthritis #PrecisionMedicine #ImmuneSystem #LongevityScience