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Repeated exposure to fatty foods like bacon and burgers drives your liver cells into survival mode to help them endure metabolic stress. That transition also sets them on a path to become cancerous in years to come.

Researchers at MIT and Harvard Medical School now report this frightening transformation in the journal Cell following their studies in a mouse model and in human liver cells using sophisticated single cell RNA sequencing. Mature liver cells, hepatocytes, that are exposed to a high-fat diet become stressed and gradually abandon their normal metabolic and detoxification functions. They revert to a primitive, stem-like state that helps them survive inflammation and fat overload but makes them vulnerable to malignant, cancerous, transformation.

The investigators observed this cell transition occurred in both the mouse and the human cells. Nearly all the mice fed the high fat diet ultimately developed liver cancer.

So take heed. Now is the time to moderate your intake of fried and excessively fatty foods. Your liver will love you for it, and your loved ones will enjoy your company far longer.

https://www.sciencedaily.com/releases/2025/12/251225035344.htm

https://cell.com/cell/retrieve/pii/S0092867425013662?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S0092867425013662?showall=true

#liver #highfat #cancer