Rob and Larry are comedy nerds. Larry Charles, the director of “Borat” and “Curb Your Enthusiasm,” joins Rob Lowe to discuss working with Bob Dylan and Larry David, the experience of shooting “Borat,” their mutual friend Arsenio Hall, his new memoir, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Rob is Sir Jonathan Pryce’s biggest fan! The legendary actor joins Rob Lowe to discuss how the late Pope Francis inspired his performance in “Game of Thrones,” acting lessons from Al Pacino, his favorite theaters to perform in, how the loss of his father inspired him to take on “Hamlet,” the new season of “Slow Horses,” and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Ralph and Rob are “Outsiders” for life. Ralph Macchio and Rob Lowe reunite in the studio to discuss “Karate Kid: Legends” (in theaters now), their memories from shooting “The Outsiders,” Ralph's star on the Hollywood Walk of Fame, the global legacy of “Karate Kid,” and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Rhett & Link are the kings of YouTube! The comedy duo joins Rob Lowe to discuss their long-running morning show, “Good Mythical Morning,” growing up together in North Carolina, their beloved YouTube taste tests, the difference between new media celebrity and old media celebrity, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Rob and Patrick are practically family! The “White Lotus” star joins Rob Lowe to discuss his father Arnold's softening with age, his experiences at the Met Gala and the Cannes Film Festival, bonding with his family on "White Lotus," and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Rob and Ike are the biggest Kate Hudson fans! Actor Ike Barinholtz (The Mindy Project, The Studio, Running Point) joins Rob Lowe to talk about their mutual friends Kate Hudson and Amy Poehler, the time Ike ate the coconut cake Tom Cruise gifted to Mindy Kaling, Rob’s look-a-like in the Lakers organization, doing improv in Amsterdam with Seth Meyers, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Penn and Rob wish they were invited to "We Are the World!" Magician, television presenter, and author Penn Jillette (of Penn & Teller) joins Rob Lowe to discuss his surprising favorite magic trick, the genius of Bob Dylan, 50 years of “Penn & Teller,” and his new novel.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Kelsey Grammer returns to "Literally” for a moving episode. The "Frasier" and "Cheers" star joins Rob Lowe to discuss his deeply cathartic new book, "Karen: A Brother Remembers," the tragic loss of his sister, his return to the world of "X-Men" and Marvel, why he still finds joy in acting, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!