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Regenerative nanomedicine researchers now report the successful regrowth of spinal cord nerve fibers while minimizing the interference of scar tissue. This from Northwestern University and published in the journal Nature Biomedical Engineering.

Investigators there engineered millimeter-scale human spinal cord organoids from stem cells and incorporated in them functional neurons. They added astrocytes and microglial immune cells in order to study repair and inflammatory processes. Using this model, the team studied two types of traumatic injury models: a laceration injury and a compression injury.

Batches of these damaged mini spinal cord organoids were treated with two types of therapeutic peptides; fast-moving supramolecules; and slower-moving versions containing the same biological signals. The slow movers drive neural regeneration while the fast movers stifle excess inflammation.

The results are striking: the treated mini-spinal cords show substantial neural regeneration with nerve extension regrowth and the notable absence of glial scar tissue. These peptide agents had shown remarkable benefits in prior animal studies. A single injection given 24 hours after severe injury enabled mice to walk again within four weeks. This lab-grown spinal cord model demonstrates the reason for this success.

Spinal cord injuries cause permanent paralysis because scar tissue blocks effective nerve regrowth. Using lab-grown mini-spinal cord tissue, this study shows that molecular therapy can reduce inflammation, shrink scar tissue, and trigger functional nerve growth. Once these techniques are refined and subjected to clinical trials, the possibility of restoring limb use after otherwise devastating spinal cord injuries could come…..someday soon.

https://www.sciencedaily.com/releases/2026/02/260216044003.htm

https://www.nature.com/articles/s41551-025-01606-2

#spinalcord #paraplegia #quadraplegia #peptides #organoids

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