Featuring an interview with Dr Jonathan Strosberg, including the following topics:

• Overview of extrapulmonary neuroendocrine carcinoma (NEC) (0:00)
• Treatment strategies for extrapulmonary NEC (10:26)
• Targeting DLL3 in extrapulmonary NEC (18:49)
• Early clinical data with obrixtamig for extrapulmonary NEC (21:56)
• Additional investigational agents for extrapulmonary NEC (25:44)
• Case: A woman in her mid 50s with poorly differentiated metastatic NEC of unknown primary (27:20)
• Case: A man in his early 60s with poorly differentiated metastatic esophageal NEC (32:30)
• Clinical management of well-differentiated NEC (36:58)

CME information and select publications

Featuring an interview with Dr Beth Faiman, including the following topics:

• Clinical practice background and historical view of treatment for multiple myeloma (MM) (0:00)
• Fundamental principles associated with chimeric antigen receptor (CAR) T-cell therapy (7:19)
• Sequencing of CAR T-cell therapy and bispecific antibodies in the MM treatment landscape (9:00)
• Patient eligibility to receive CAR T-cell therapy (13:23)
• Differentiating among approved CAR T-cell therapies for MM (18:18)
• Durability of responses to CAR T-cell therapy for MM (24:01)
• Neurotoxicity with CAR T-cell therapies for MM (26:26)
• Minimal residual disease monitoring in MM (29:39)
• Support systems for the management of toxicities associated with CAR T-cell therapy (35:10)
• Patients with MM experiencing durable responses to CAR T-cell therapy (43:11)

NCPD information and select publications

Featuring a slide presentation and related discussion from Dr Jonathan Strosberg, including the following topics:

• Overview of the classification, grading and incidence of neuroendocrine carcinoma (NEC) (0:00)
• Overview of mutational profile, biomarker assessments and prognosis of NEC (3:45)
• Current treatment paradigm for extrapulmonary NEC (8:59)
• DLL3 as an emerging target biomarker in extrapulmonary NEC (17:46)
• Novel therapeutic agents under investigation for extrapulmonary NEC (23:05)

CME information and select publications