Page de couverture de Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

Auteur(s): David Brühlmann - CMC Development Leader Biotech C-level Advisor Business Strategist
Écouter gratuitement

À propos de cet audio

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.

**TOP 10 LIFE SCIENCES PODCAST**

Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?

Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?

Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?

There's a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver your groundbreaking therapy to clinics and market without delay, and still enjoy every single step.

I'm David Brühlmann, a biotech entrepreneur and strategic advisor who partners with C-level biopharma leaders to tackle one of our industry's biggest challenges: reducing manufacturing costs to make lifesaving therapies accessible to more patients worldwide.

Through engaging conversations with industry pioneers and practical insights from the trenches, this podcast tackles the critical challenges in bioprocess CMC development and manufacturing of recombinant proteins and cell and gene therapy products. We cut through the complexity so you can:

  • Master bioprocess development with confidence and clarity


  • Excel at scale-up and manufacturing of biologics


  • Transform your innovative therapy and manufacturing technology into market-ready solutions faster


  • Optimize manufacturing costs without compromising quality


  • Make data-driven decisions that reduce the risk of failure


I can’t wait to help you do biotech the smart way.

Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.

Ready to transform your biomanufacturing journey? Let's dive in!

Next Steps:

Book a free call to reduce biomanufacturing costs and make lifesaving therapies more accessible: https://bruehlmann-consulting.com/call

Fast-track bioprocess development with expert guidance: https://bruehlmann-consulting.com

Visit the Website: https://smartbiotechscientist.com

Email us: hello@bruehlmann-consulting.com

© 2025 Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation
Science Sciences biologiques
Épisodes
  • 173: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist Gernaey - Part 1
    Jul 22 2025

    Are you struggling to bridge the gap between lab-scale models and commercial bioprocessing reality? For many biotech innovators, the promise of digital twins meets harsh industrial constraints - where hybrid models that excel in controlled lab environments must prove themselves in the complexity of large-scale manufacturing.

    This week on the Smart Biotech Scientist Podcast, host David Brühlmann welcomes Krist Gernaey, Professor of Industrial Fermentation Technology at the Technical University of Denmark. With expertise spanning measurement technology development and two decades pioneering hybrid model digital twins for bioprocess applications, Krist reveals the critical gap between digitalization hype and industrial implementation reality.

    Here are three key reasons this episode will level up your hybrid modelling and digital twin approaches.

    • From Data Overload to Intelligent Control: Raw sensor data means nothing without the right models to interpret it. Krist demonstrates how hybrid model digital twins convert complex bioprocess measurements into actionable control strategies - showing why sophisticated algorithms need simple, robust sensors to succeed at commercial scale.
    • From Individual Genius to Team Implementation: The most elegant digital twin fails without operator buy-in. Krist shares why successful commercial bioprocessing depends on bridging academic innovation with frontline manufacturing expertise - revealing the human factors that make or break advanced modeling initiatives.
    • From Lab Perfection to Commercial Pragmatism: Discover why the most promising hybrid modeling approaches must balance mechanistic understanding with data-driven adaptation. Krist provides a reality check on electrochemical sensors, validation challenges, and the strategic decisions that determine whether digital twins deliver commercial value or remain expensive experiments.

    Ready to master the art of scaling hybrid model digital twins from promising lab tools to commercial bioprocessing game-changers? Tune in to discover Krist Gernaey's battle-tested strategies for navigating the complex journey from academic innovation to industrial impact.

    Connect with Krist Gernaey:

    LinkedIn: www.linkedin.com/in/krist-gernaey-591748

    Website: www.orbit.dtu.dk/en/persons/krist-v-gernaey

    If you’re intrigued by the evolving frontier of bioprocessing, don’t miss these enlightening episodes:

    • Episodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo Morbidelli
    • Episodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago Matos
    • Episodes 05-06: Hybrid Modeling: The Key to Smarter Bioprocessing with Michael Sokolov

    Next step:

    Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call

    Develop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at https://stan.store/SmartBiotech

    Support the show

    Voir plus Voir moins
    21 min
  • 172: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 2
    Jul 17 2025

    Downstream processing remains one of the most complex and critical steps in biomanufacturing, especially as new therapeutic modalities like cell and gene therapies push current technologies to their limits. The industry faces ongoing pressure to innovate, reduce costs, and improve efficiency, while still ensuring robust and reliable results.

    In this practical, energetic episode, host David Brühlmann welcomes Scott Wheelwright, Chairman, CTO and Co-Founder of BioChromatographix International (BCI). With a career spanning continents - Asia, Europe, and North America - Scott's perspective is forged from hands-on manufacturing, technology transfer, and building high-growth companies from scratch. He’s not just innovating the science behind chromatography; he’s lived the manufacturing realities, spanning everything from precision antibodies to complex gene therapies, and now leads a team solving the tough purification puzzles holding progress back.

    Here are three reasons why this episode is a must-listen:

    • Continuous Innovation in Chromatography: Despite a hundred-year legacy, chromatography still holds tremendous untapped potential, especially with new materials and continuous processing, as Scott highlighted with real examples from gene and cell therapy applications.
    • Bridging Lab to Market Needs Customer Focus: Getting new technology into commercial use requires not just technical innovation, but deep user engagement, robust feedback loops, and iterative improvement, plus ongoing education to help users understand new benefits.
    • Embrace Experimentation and Global Collaboration: Whether building companies in Asia, Europe, or the U.S., Scott reminds us that learning from failure, being open to international collaboration, and not being afraid to try new things are essential for long-term growth (and enjoying the biotech journey along the way!).

    If you’re passionate about downstream processing, tech innovation, or just want to hear inspiring leadership lessons, check out the full episode and connect with Scott Wheelwright or visit the company’s website to follow his team’s advancements.

    Connect with Scott Wheelwright:

    LinkedIn: www.linkedin.com/in/scottmwheelwright

    Website: www.biochromatographix.com

    Curious about chromatography? Tune in to hear what our previous guests had to say!

    • Episodes 119-120: Innovating Protein Purification Using Synthetic Organelles and AI with Haotian Guo
    • Episodes 61-62: Magnetic Bead Technology: The New Era in Downstream Processing with Nils Brechmann
    • Episodes 37-38: How to Master Downstream: A Deep Dive Into Bioprocessing Purification with Wei Zhang

    Next step:

    Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call

    Develop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at https://stan.store/SmartBiotech

    Support the show

    Voir plus Voir moins
    20 min
  • 171: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 1
    Jul 15 2025

    For decades, chromatographic purification has made use of bead-based diffusion - a reliable but limiting approach, especially as new modalities like gene therapies, mRNA, and viruses push the boundaries of what’s possible. But what if the future of downstream processing lies not in incremental improvement, but in a dramatic reimagining - from slow diffusion to rapid convection?

    In this episode, David Brühlmann meets Scott Wheelwright, Chairman, CTO and Co-Founder of BioChromatographix International (BCI). Scott brings decades of expertise in biopharmaceutical development and manufacturing. Prior to BCI, he co-founded Biolnno Bioscience, a leading CDMO, and co-founded Innovent Biologics, one of China’s foremost biotechnology companies.

    Here are three compelling reasons to tune into this episode:

    • Breaking the Mold of Purification: BCI’s AXISFLOW™ Platform moves beyond bead-based processes, using advanced 3D-printed monoliths that enable convective flow, making purification of large biomolecules and viruses faster, more efficient, and better suited for next-generation therapies.
    • Innovation Starts with Imagination (and Measurement): True progress in bioprocessing often hinges not on what we can make, but on what we can accurately measure and imagine. Scott reminds us that advances in analytical testing and creative thinking are the real engines of change.
    • Biotech Demands More than Great Science: Success isn’t just about inventing; it’s about building with the end-user in mind. Scott’s journey highlights the critical role of customer-centric product development, cross-disciplinary teamwork, and regulatory strategy - especially in a conservative, risk-averse industry.

    Curious how shifting from diffusion to convection could reshape your purification workflow? Listen to this episode and discover how to unlock efficiency, cut costs, and deliver therapies that might otherwise remain out of reach.

    Connect with Scott Wheelwright:

    LinkedIn: www.linkedin.com/in/scottmwheelwright

    Website: www.biochromatographix.com

    Curious about chromatography? Tune in to hear what our previous guests had to say!

    • Episodes 119-120: Innovating Protein Purification Using Synthetic Organelles and AI with Haotian Guo
    • Episodes 61-62: Magnetic Bead Technology: The New Era in Downstream Processing with Nils Brechmann
    • Episodes 37-38: How to Master Downstream: A Deep Dive Into Bioprocessing Purification with Wei Zhang

    Next step:

    Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call

    Develop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at https://stan.store/SmartBiotech

    Support the show

    Voir plus Voir moins
    21 min

Ce que les auditeurs disent de Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

Moyenne des évaluations de clients

Évaluations – Cliquez sur les onglets pour changer la source des évaluations.