Welcome to the 30th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with senior author Professor Gabor G Kovacs of the Brain article entitled: Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy

Listen to the fascinating insights exploring the autoimmune side of progressive supranuclear palsy (PSP) following identification of cytotoxic T cells within the mid-brain of PSP post-mortem tissue. The pattern of T cells appears to follow both temporal progression of underlying PSP and may also relate to rate of disease progression. Professor Kovacs discusses potential autoimmune treatment in a neurodegenerative disorder, such as PSP, and others.

Check out the full article on the Brain website as part of the August 2025 issue: https://doi.org/10.1093/brain/awaf135

This episode was co-hosted, edited and produced by David Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 29th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author of the Brain article entitled: Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis

We are joined by Alida Chen for an interesting discussion into detecting transcriptional changes that may identify efficient remyelination in multiple sclerosis. Using brain bank donor tissue, the authors examine donors who show efficient remyelination compared with those who had poorly remyelinating lesions. They discuss interesting findings around the epithelial–mesenchymal transition pathway as well as the MTORC1 signalling pathway. Further, the team discusses how these findings may translate to in vivo understanding of efficient remyelination in patients with MS as well as other experimental models that may help elucidate this.

Check out the full article on the Brain website as part of the June 2025 issue: https://doi.org/10.1093/brain/awae414

This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 28th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with three authors of the Brain article entitled: The relationship between kidney health and neurodegenerative diseases

Ms Melody Zuo, Dr Le Chang and Professor Sarah A Gagliano Taliun grace the Brain podcast with an insightful discussion into their recent review examining the connection between kidney disease and neurogeneration. They describe the critical microvascular connection as well as the role of uraemia and small molecules like erythropoetin. Additonally, methodological issues around survival bias, the use of mendelian randomisation and the importance of metadata in the growing age of large available datasets.

Check out the full article on the Brain website and will be part of the August 2025 issue: https://doi.org/10.1093/brain/awaf113

This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.