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The Peptide Podcast

The Peptide Podcast

Auteur(s): The Peptide Queen
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 The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach. We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more. We give you accurate, unbiased information so you can choose the peptides that suit YOU best. In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most. About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics. She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.This website and its content are copyright of The Peptide Podcast - All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited. Entraînement physique et mise en forme Hygiène et mode de vie sain Mise en forme, régime et nutrition Médecine alternative
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  • Pancragen

    Pancragen
    Sep 18 2025
    Today, I want to shine a light on a fascinating, little-known peptide called Pancragen. And if you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. https://pepties.com/partners/ Now, if you’ve been following the world of anti-aging and metabolic optimization, you probably know about GLP-1 medications, metformin, and other mainstream therapies—but Pancragen is something a bit different. It’s a tiny peptide with a big mission. That is rejuvenating your pancreas and restoring metabolic function. And trust me, the science behind it is pretty remarkable. What is Pancragen? So here’s the story—Pancragen was developed by a team of Russian researchers led by Professor Vladimir Khavinson in St. Petersburg. These are the same minds behind legendary peptides like Epitalon and Thymalin. What they discovered was pretty fascinating. In the bovine pancreas, they found a tiny tetrapeptide—just four amino acids—that acts like a molecular switch for keeping your pancreas youthful. The full sequence is Lysine, Glutamic acid, Aspartic acid, and Tryptophan. Now, in biochemistry, we usually shorten these with a one-letter code, so Lysine becomes K, Glutamic acid is E, Aspartic acid is D, and Tryptophan is W—which is why this peptide is known as KEDW. Pancragen was created to mimic that exact peptide. And over decades of studies in both animals and humans, the results have been honestly amazing. How Pancragen Works Here’s where it gets really exciting. Unlike most medicaitons that act broadly and non-specifically in the body, Pancragen is precise. When you inject it under the skin, it travels through your bloodstream straight to the pancreas. And get this—it can even enter the nucleus of pancreatic cells and interact with the DNA that controls key genes for insulin and enzyme production, like Pdx1, Ptf1a, and Pax6. Pdx1 is essential for insulin production, Ptf1a helps pancreatic cells make digestive enzymes, and Pax6 keeps the insulin-producing cells functioning properly. Basically, Pancragen flips these genes back on, helping pancreatic cells survive, grow, and work efficiently. The result? Better insulin regulation, improved enzyme production, and a pancreas that behaves years younger—think of it like updating your pancreas’s software to the latest version. What the Studies Show Let’s talk numbers. In aging patients with type 2 diabetes, Pancragen reduced fasting blood glucose by 20–25% and improved post-meal glucose even more. Even better, patients needed up to 35% less insulin for the same level of glucose control—meaning their cells became more sensitive to insulin rather than being forced to overwork. In primate studies, old monkeys treated with Pancragen actually outperformed those on glimepiride, a standard diabetes medication. Pancragen restored normal insulin and C-peptide rhythms without forcing the pancreas into burnout—and these effects lasted for weeks after treatment ended. And here’s a bonus: Pancragen also normalizes melatonin secretion, which helps improve sleep, circadian rhythm, and overall metabolic health. So it’s not just about blood sugar—it’s a full-spectrum metabolic reset. Safety and Benefits Pancragen has been on the market in Eastern Europe for over a decade with no reported toxicity or adverse interactions. It simply breaks down into regular amino acids when its job is done. Users report: More stable blood sugar and fewer hypoglycemic events Reduced insulin requirements Better digestion and enzyme function Increased energy and fewer “hangry” moments A general feeling of metabolic youthfulness/health And because it works at the gene-expression level, these benefits can last for weeks or months after a cycle of Pancragen. Who Should Consider Pancragen? So, who is Pancragen for? People with type 2 diabetes or prediabetes: Pancragen helps restore normal pancreatic function, improving insulin production and glucose control instead of just masking symptoms. Those with chronic pancreatitis or enzyme insufficiency: By supporting pancreatic cells and enzyme production, it can help the pancreas work more efficiently, which may ease digestive issues. Older adults looking for metabolic anti-aging support: Pancragen can rejuvenate pancreatic function, improve insulin sensitivity, and support overall metabolic health—essentially helping the body act younger. Athletes or high-performers wanting optimal metabolic efficiency: Better pancreatic function means more precise insulin and enzyme regulation, supporting energy, recovery, and performance. People looking to prevent a plateau from GLP-1 therapy: Over time, some GLP-1 users hit a point where their progress stalls. Pancragen may help “reset” the pancreas so therapy stays effective. But keep in mind, if you’re just after a quick appetite suppressant, Pancragen isn...
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    7 min
  • TB-4 vs TB-500 — Clearing Up the Confusion

    TB-4 vs TB-500 — Clearing Up the Confusion
    Sep 11 2025
    Today we’re tackling a question I hear all the time: What’s the difference between thymosin beta-4 and TB-500? These two names often get tossed around like they’re the same thing — but they’re not. I’ve touched on this before, but because it can get pretty confusing, I want to break it down in more depth today. And if you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. -> https://pepties.com/partners/ We’ll break down how each peptide works, the potential benefits and side effects we know about, what their half-lives look like, and why dosing often ends up being two to three times a week — even though technically you could dose daily at lower amounts. I also want to note that we’ll talk specifically about subcutaneous use, since that’s how these peptides are most often used in practice. What is Thymosin beta-4 and TB-500? Let’s start simple. Thymosin beta-4, or Tβ4, is the full-length natural peptide — it’s 43 amino acids long, and your body actually makes it. You’ll find it in platelets, white blood cells, and tissues all over the body. It helps with wound healing, new blood vessel growth, reducing inflammation, and keeping cells moving where they need to go. On the other hand, TB-500 is a synthetic (man-made) fragment of Tβ4 — basically, chemists figured out that a small part of the Tβ4 sequence, specifically the section that binds actin, or the 17-23 fragment, that seemed to carry a lot of the healing and regenerative activity. The tricky part is, TB-500 isn’t always just that one fragment. Let me try to explain this very confusing concept. Most of the time, when people say TB-500, they’re talking about the 17–23 fragment — the piece linked to actin binding and tissue repair. But full-length thymosin beta-4 can actually break down into several different active fragments, like Ac-SDKP, the 1-4 section, the 4-10 section, and even the 20–35 region — and each of those has its own unique effects on healing, inflammation, or fibrosis. Something we can discuss in another podcast. The focus today will be on the full-length, naturally occurring 43-amino acid peptide and the common N-acetylated 17-23 fragment often referred to as TB-500. So think of it this way: Tβ4 is the whole book, TB-500 is one powerful chapter. How does thymosin beta-4 and TB-500 work? Both thymosin beta-4 and TB-500 are best known for their role in tissue repair and recovery — but the way they work isn’t identical. They both help guide cells to where they’re needed after an injury, a process called cell migration. They also help prevent or limit scar tissue, improve blood flow by encouraging angiogenesis — the growth of new blood vessels — and help settle down excessive inflammation so healing can happen. Where they start to differ is in their scope. The full-length thymosin beta-4 is like the master version. Because it’s the entire 43–amino acid chain, it has more binding sites and interacts with more pathways. That gives it a broader range of effects — it’s been studied not just for wound healing, but also for heart repair after a heart attack, corneal healing in eye injuries, nerve and brain protection after trauma, and even immune system modulation. TB-500, on the other hand, is a synthetic fragment that contains the ‘active core’ sequence responsible for actin binding. This means it still boosts cell migration and new blood vessel growth, which are huge for recovery, but it doesn’t have all the extra regulatory sections of the full Tβ4 molecule. Because of that, TB-500 tends to be seen as more targeted — very good at tissue and tendon repair, wound closure, and improving circulation, but without the same wide-ranging effects on the heart, brain, or immune system that you see with the complete Tβ4 peptide Half-Life and Dosing Okay, let’s talk about half-life, because this confuses people all the time. Tβ4 has a short plasma half-life in humans — about one to two hours after IV dosing. That sounds super quick, right? But here’s the kicker: just because it clears from the blood doesn’t mean the effects are gone. Once it gets into tissues, it kicks off repair programs that can last for days. TB-500 hasn’t been studied as thoroughly in humans, so we don’t have published plasma half-life numbers you can point to. What we do know from animal and lab studies is that the fragment is also cleared pretty quickly, but the biological effects last much longer than the detectable levels in blood likeTβ4. That’s why protocols often use two or three injections per week rather than daily. Now, could you take either one every day? Technically, yes — especially at lower doses, and that’s actually been done in clinical research with the full-length thymosin beta-4. But in the peptide therapy world, particularly with TB-500 ...
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    12 min
  • Food Anxiety and GLP-1’s

    Food Anxiety and GLP-1’s
    Sep 4 2025
    Today we’re diving into a topic that a lot of people struggle with quietly but don’t always feel comfortable talking about: food anxiety. And if you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Maybe you’ve felt nervous about going to a party because you weren’t sure what kind of food would be there. Or maybe you’ve found yourself planning your entire day around what you’ll eat and how to control it. Perhaps you’ve even finished a meal only to have guilt set in right away. That’s what food anxiety looks like—and you are definitely not alone. Today we’re going to talk about what food anxiety actually is, why it shows up, what you can do to calm it, and even how some of the newest medications—things like GLP-1s and dual GIP/GLP-1s—may actually help by quieting some of the mental “food noise.” What is food anxiety? At its core, food anxiety is stress or fear around eating. And the thing is, it doesn’t look the same for everyone. For one person, it might show up as constantly worrying they’ll overeat. For another, it’s that lingering guilt after eating something they feel they “shouldn’t have.” And sometimes it’s more subtle than that—like a constant hum in the background of your mind where you’re thinking about food all day, even when you’re not hungry. I often describe it like having a radio station in your brain that’s tuned into “food talk.” Sometimes it’s background noise, sometimes it’s blaring, but either way, it’s draining. And over time, that stress around eating chips away at both your mental and physical health. Why does food anxiety happen? So why does this happen in the first place? A big part of it is the culture we live in. For decades, we’ve been bombarded with messages that carbs are bad, fat is bad, sugar is the enemy—and the list keeps changing. That constant labeling of food as “good” or “bad” teaches us to feel guilty when we eat the so-called wrong thing. For others, food anxiety starts when they get a medical diagnosis. If you’ve been told you have diabetes, heart disease, or that you need to lose weight for health reasons, suddenly every single bite can feel like a math problem. You’re not just eating—you’re calculating, you’re worrying, you’re second-guessing. And then there’s the way dieting itself messes with our natural signals. When we spend years restricting, counting, and controlling, we often lose touch with our body’s hunger and fullness cues. Instead of trusting how we feel, we rely on rigid rules. And when those rules get broken, the anxiety hits hard. And finally, we can’t ignore biology. Food, especially highly processed food, lights up reward pathways in the brain. For some people, those signals are incredibly strong—stronger than for others. That means more cravings, more urges, and unfortunately, more guilt when they give in. What can you do about food anxiety behaviorally? Now, here’s the good news. There are things you can do to reduce food anxiety, and you don’t need to overhaul your entire life to start seeing changes. One of the simplest but most powerful tools is mindful eating. And I know that phrase gets thrown around a lot. But at its heart, mindful eating just means slowing down. It means actually tasting your food, noticing the textures, and checking in with how your body feels. When you slow down enough to notice satisfaction, you’re much more likely to stop eating when you’re comfortable instead of stuffed—and that takes a lot of the stress out of the meal. Another shift that helps tremendously is dropping the “good” and “bad” food labels. Health isn’t decided by one cookie, just like it isn’t guaranteed by one salad. What matters is your overall pattern, week by week, month by month. When you start to see food as neutral—as fuel, as enjoyment, as part of life—it loosens the grip of guilt and allows you to be more flexible. And speaking of flexibility, having a loose structure around meals can be calming. Instead of rigid dieting rules, like “I can never eat after 7 p.m.,” focus on balance. A meal that has some protein, some fiber, and a little healthy fat is naturally stabilizing. It helps keep blood sugar steady, which means fewer spikes and fewer crashes. And when your body feels stable, your brain feels calmer, too. It’s also worth paying attention to your personal triggers. For some people, weekly weigh-ins, keeping a food log, or using a nutrition app can be helpful. But for others, they actually fuel the anxiety. If you notice those things making you more stressed rather than less, it’s okay to step away from them. You can still eat intentionally without logging every single bite. And while we are on the subject of personal triggers like daily or weekly weigh-ins, I want to talk about this a bit...
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    10 min
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