The tropical Asian tree kratom – a member of the same botanical family that has given us both coffee and quinine – is showing great potential for successfully treating a variety of serious afflictions, from stress to opioid withdrawal. Ironically – depending on dosage – it can act either as a stimulant or a sedative. The episode features an insightful interview with Dr. Christopher McCurdy, the leading authority on this extraordinary plant of the gods.

Show notes:

“About Christopher R McCurdy.” University of Florida College of Pharmacy, pharmacy.ufl.edu/profile/mccurdy-christopher/. Accessed 17 June 2025.

Grundmann, Oliver, et al. “Not All Kratom Is Equal: The Important Distinction between Native Leaf and Extract Products - Grundmann - 2024 - Addiction - Wiley Online Library.” Wiley Online Library, 9 Oct. 2023, onlinelibrary.wiley.com/doi/10.1111/add.16366.

Smith, Kirsten E., et al. “The Rise of Novel, Semi-Synthetic 7-Hydroxymitragynine Products.” Wiley Online Library, 3 Dec. 2024, onlinelibrary.wiley.com/doi/10.1111/add.16728.

Talesnik, Dana. “McCurdy Studies Whether Kratom Can Reduce Opioid Withdrawal, Ease Pain.” National Institutes of Health, U.S. Department of Health and Human Services, 23 June 2022, nihrecord.nih.gov/2022/06/24/mccurdy-studies-whether-kratom-can-reduce-opioid-withdrawal-ease-pain.

The lure of lost cities is a deep and enduring fascination that combines equal parts mystery, adventure, treasure, and the promise of forgotten knowledge. The existence and discovery of these ruins – whether it was King Tut's tomb or Machu Picchu – demonstrates the brilliance of ancient civilizations and their impermanence and mortality. In this episode, host Mark Plotkin recounts his experience as part of an expedition in search of the so-called "Lost City of the Monkey God," as well as the role that hallucinogens and shamanism played in helping us understand some of the artwork and cultures of these ancient peoples.

Episode Notes

The therapeutic benefits of ayahuasca are well-known and celebrated worldwide. However, when conducted by the wrong individuals, ayahuasca ceremonies can also lead to harmful outcomes. In this episode, host Mark Plotkin talks with author and explorer Robert Tindall about some of the potential risks and downsides of ayahuasca use.