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Two guys talking **it - A Gastroenterology and Hepatology podcast

Two guys talking **it - A Gastroenterology and Hepatology podcast

Auteur(s): A/Prof Jon Segal and Dr James Haridy
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À propos de cet audio

 “Two Guys Talking $#it” is a podcast where two Gastroenterologists break down complex topics into engaging, educational, and occasionally humorous conversations. From liver health to gut microbiota and everything in between, A/Professor Jonathan Segal and Dr James Haridy deliver insights, share the latest research, and discuss clinical pearls with the odd guest in tow. Comments, suggestions, questions please contact us on twitter @2guystalkingit or leave a comment below..A/Prof Jon Segal and Dr James Haridy Hygiène et mode de vie sain Troubles et maladies
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  • #10: A/Prof Gianluca Ianiro and Dr Benjamin Mullish - The gut microbiome in health and disease

    #10: A/Prof Gianluca Ianiro and Dr Benjamin Mullish - The gut microbiome in health and disease
    Jul 9 2025

    Today we’re talking bugs, bowels, and breakthroughs with A/Prof Gianluca Ianiro and Dr. Ben Mullish, two microbiome maestros who make poo science strangely fascinating.


    A/Prof Gianluca Ianiro is an Associate Professor of Gastroenterology at the Università Cattolica del Sacro Cuore in Rome and a Consultant at the Gastroenterology Unit of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS. His clinical and research interests center on the gut microbiota, with a particular emphasis on fecal microbiota transplantation (FMT) and its applications in gastrointestinal disorders such as Clostridioides difficile infection and irritable bowel syndrome. Recognized as a leading expert in his field, Professor Ianiro has contributed extensively to international consensus guidelines and has been acknowledged for his work with the United European Gastroenterology Rising Star award. He also leads the Microbiome Clinic at Gemelli, translating cutting-edge microbiome research into clinical practice.


    Dr. Benjamin Mullish is a Senior Clinical Research Fellow in the Division of Digestive Diseases at Imperial College London and an Honorary Consultant in Hepatology and Gastroenterology at St Mary’s Hospital, part of the Imperial College Healthcare NHS Trust. He is also an IPPRF Research Fellow within the Department of Metabolism, Digestion and Reproduction at Imperial College. His research focuses on the gut microbiome and faecal microbiota transplantation (FMT), particularly in the context of liver disease and gastrointestinal infections.This conversation delves into the complexities of the microbiome, particularly the gut microbiome, and its significant role in health and disease.


    We discuss the dynamic nature of the microbiome, the challenges in microbiome research, and the potential for microbiome-based therapeutics. They also explore the roles of prebiotics and probiotics, the future of microbiome diagnostics, and the potential future concept for specialised microbiome clinicians to bridge the gap between research and clinical practice.


    As always comments, questions and feedback please send to: X: @2guystalkingit

    Email: 2guystalkingit@gmail.com


    Chapters

    00:20 J + J Introduction

    05:11 Introduction to the Microbiome

    07:16 Understanding the Gut Microbiome

    10:04 The Dynamic Nature of the Microbiome

    13:21 Factors Influencing the Gut Microbiome

    16:15 Clinical Relevance of Stool Microbiome

    19:24 Microbiome and Disease: Cancer and Liver Health

    22:12 Microbiome in Inflammatory Bowel Disease (IBD) and Metabolism

    25:20 Future Directions in Microbiome Research

    35:20 The Uncertainty of Microbial Therapeutics

    37:10 The Future of Microbiome Research

    42:41 Understanding Prebiotics and Probiotics

    56:49 The Need for Microbiome Clinician specialists
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    1 h et 3 min
  • #09: A/Professor Emma Halmos & Dr CK Yao - Food is Medicine.. or is it?

    #09: A/Professor Emma Halmos & Dr CK Yao - Food is Medicine.. or is it?
    Jun 5 2025
    Today we welcome two world-leading dietitians to talk all things diet in IBD and IBS....A/Prof Emma Halmos is a senior research dietitian at Monash University and the Alfred Hospital. Her scientific achievements have had a major impact in clinical practice nationally and internationally. The most notable was the pivotal feeding study that demonstrated the low FODMAP diet was efficacious in patients with IBS. A/Prof Halmos has been elected onto the D-ECCO (Dietitians of European Crohn’s and Colitis Organisation) committee and is a leading coordinator for the first ECCO guidelines on nutrition in IBD. Her current role at Monash University is leading research on novel dietary therapy to treat IBD and IBS.Dr CK Yao is a senior research dietitian at Monash University and the Alfred Hospital, and recent NHMRC emerging leader. In 2017, CK completed her PhD investigating dietary manipulation of gut microbial function and the application of gaseous biomarkers in patients with functional and inflammatory bowel disease. Dr Yao currently leads a research programme looking at optimising dietary strategies for patients with ulcerative colitis and those with an ileoanal pouch.We discuss the critical role of diet in managing inflammatory bowel disease (IBD), particularly Crohn's disease and ulcerative colitis. We explore various dietary patterns, the impact of emulsifiers and ultra-processed foods, and the importance of personalized dietary advice. We talk about the significance of dietitians in guiding patients towards healthier choices. This conversation delves into the complexities of dietary recommendations for various gastrointestinal conditions, particularly focusing on the Mediterranean diet, Crohn's disease, and IBS. We discuss cultural influences on diet, the importance of personalized nutrition, and the emerging trends in dietary therapy. Finally we touch on the new ECCO Diet in IBD guideline that is set to be published soon.As always comments, questions and feedback please send to: X: @2guystalkingitEmail: 2guystalkingit@gmail.comChapters00:00 Introduction with J & J4:20 On to our guests... Diet and IBD05:50 Dietary Patterns for Disease Prevention08:53 Therapeutic Diets and Active IBD11:58 Controversies in Dietary Recommendations15:02 The Impact of Emulsifiers and Ultra-Processed Foods18:07 Practical Dietary Advice for Patients in IBD21:02 Cultural Considerations in Dietary Recommendations23:57 Food as Medicine: A Discussion27:03 Exploring Diverse Dietary Patterns30:13 Conclusion and Future Directions32:26 Cultural Influences on Diet and Health34:40 Dietary Recommendations for active Crohn's Disease37:22 Understanding Pouch Patients38:11 Initial Assessment for IBS Patients44:25 Screening for ARFID48:03 Emerging Dietary Trends in IBS51:40 New Guidelines in IBD NutritionPapers discussedFitzpatrick JA, Gibson PR, Taylor KM, Anderson EJ, Friedman AB, Ardalan ZS, Smith RL, Halmos EP. Clinical Trial: The Effects of Emulsifiers in the Food Supply on Disease Activity in Crohn's Disease: An Exploratory Double-Blinded Randomised Feeding Trial. Aliment Pharmacol Ther. 2025 Apr;61(8):1276-1289. https://pubmed.ncbi.nlm.nih.gov/39967287/Fitzpatrick JA, Gibson PR, Taylor KM, Halmos EP. Development of Novel High and Low Emulsifier Diets Based upon Emulsifier Distribution in the Australian Food Supply for Intervention Studies in Crohn's Disease. Nutrients. 2024 Jun 18;16(12):1922. . https://pubmed.ncbi.nlm.nih.gov/38931276/Halmos EP, Gibson PR. Controversies and reality of the FODMAP diet for patients with irritable bowel syndrome. J Gastroenterol Hepatol. 2019 Jul;34(7):1134-1142. https://pubmed.ncbi.nlm.nih.gov/30945376/A FODMAP Gentle approach: https://www.monashfodmap.com/blog/gentle-fodmap-diet/The SCOFF Questionnaire: https://ceed.org.au/wp-content/uploads/2024/05/SCOFF.pdf
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    56 min
  • #08: Professor Gideon Hirschfield - The Art and Science of PSC and Autoimmune Hepatitis

    #08: Professor Gideon Hirschfield - The Art and Science of PSC and Autoimmune Hepatitis
    Apr 28 2025

    Summary

    Dr Gideon Hirschfield is a leading expert in autoimmune liver diseases, including PSC, PBC, and autoimmune hepatitis. He’s helped shape how these conditions are understood and managed around the world, combining cutting-edge research with a real passion for patient care.

    Today he discusses his work with autoimmune liver diseases, particularly primary sclerosing cholangitis (PSC) and autoimmune hepatitis. We discuss some key topics in PSC (including use of Ursodeoxycholic acid, cancer surveillance as well as the PSC/IBD phenotype), and Professor Hirschfield gives us a masterclass in the management of autoimmune hepatitis. He also offers advice for new hepatologists, highlighting the significance of clear diagnoses, individualized patient management, and clinical trials to drive us into the future.


    As always comments, questions and feedback please send to: X: @2guystalkingit

    Email: 2guystalkingit@gmail.com


    Chapters

    00:30 J & J Introduction

    06:15 Introduction to Professor Hirschfield and Autoimmune Liver Diseases

    07:41 The Role of Ursodeoxycholic Acid in PSC Management

    19:06 Understanding the Pathophysiology of PSC

    22:43 Cancer Surveillance in PSC Patients

    28:39 The Relationship Between PSC and Inflammatory Bowel Disease

    32:30 Vancomycin and PSC

    36:28 Management Strategies for PSC and IBD Patients including Pouches

    40:00 Management of Autoimmune Hepatitis: An Art and Science

    56:30 Proactive Approaches in Primary Biliary Cholangitis (PBC) Management

    1:01:05 Advice for Aspiring Hepatologists


    Keywords

    Hepatology, Autoimmune Liver Disease, PSC, Ursodeoxycholic Acid, Cancer Surveillance, Inflammatory Bowel Disease, Clinical Trials, Patient Care, Liver Transplantation, PSC Management, pouch studies, autoimmune hepatitis, management, PBC, hepatology, patient choices, liver transplant, treatment options, chronic diseases, clinical trials
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    1 h et 6 min

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