What if the biggest lever for improving U.S. healthcare isn’t clinical, but operational?

In this episode, recorded live at New York Tech Week, a16z General Partner David Haber speaks with Trey Holterman (Tennr) and Christophe Rimann (Camber), two founders tackling the core infrastructure problems slowing healthcare down - from broken referral handoffs to denied insurance claims.

They discuss building trust in high-stakes workflows, how better incentives (not just better tech) drive adoption, and why the most defensible products aren’t just smart - they work 97%+ of the time.

Plus: advice for founders, the cultural edge of New York startups, and what they’d fix first if they ran HHS.

Timecodes:

00:00 Introduction to Healthcare Payment Innovation

00:48 Meet the Founders: Trey Holman and Christophe Reman

02:31 The Broken Healthcare System: Identifying the Problems

03:47 The Why Now: Technological and Market Shifts

05:29 Understanding the Customers and Their Needs

06:34 Challenges and Misconceptions in Healthcare Technology

08:31 Building a Company in New York City

10:29 Leveraging AI and Technology for Better Outcomes

12:29 Defensibility and Differentiation in Healthcare Solutions

15:28 Impact on Providers and Patients

18:09 Advice for Aspiring Healthcare Entrepreneurs

23:17 Conclusion and Final Thoughts

Resources:

Find David on X: https://x.com/dhaber

Find Trey on LinkedIn: https://www.linkedin.com/in/trey-holterman

Find Christophe on X: https://www.linkedin.com/in/christopherimann/

For the past 20 years, consumer technology has been shaped by the same form factors: apps and touchscreens on smartphones. But advances in AI, wearables, and hardware could introduce an entirely new stack—creating a more agentic, adaptive, and immersive computing experience for users everywhere.

Drawing on his early days building Facebook’s News Feed to his work today on smart glasses and AR headsets, Meta CTO Andrew Bosworth joins a16z Growth General Partner David George to share how he's translated emerging technologies into products people use and love. He also explores how breakthroughs in AI and hardware could turn the existing app model on its head, introduce entirely new competitive dynamics and business models for startups, and usher in a post-mobile phone era. If we get it right, Bosworth says, the next wave of consumer tech won’t run on taps and swipes—it’ll run on intent.

Read more, including a full transcript, here: a16z.com/after-mobile-consumer-tech-andrew-bosworth

• [00:00:00] The future of content consumption
• [00:02:18] Building great products on the backs of tech trends
• [00:08:24] The evolution of Reality Labs and imagining a post-mobile world
• [00:11:36] Building a bridge to the post-mobile era
• [00:15:00] Does AI turn the app model on its head?
• [00:21:28] Competing on performance and price in the AI era
• [00:24:27] Open source, Llama, and commoditizing your complements
• [00:27:49] Risks to the post-mobile vision
• [00:32:41] Committing to the vision

In our conversation series AI Revolution, we ask industry leaders how they’re harnessing the power of generative AI and steering their companies through the next platform shift. Find more content from our AI Revolution series on www.a16z.com/AIRevolution

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment, digital asset, or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Technology doesn’t grow in isolation—it evolves in waves. Just as mobile, cloud, and social shaped the internet of the past 20 years, so too could crypto, AI, and new hardware usher in an era of the internet that’s pro-innovation, pro-startup, and pro-creator.

Speaking with a16z Growth General Partner David George, a16z crypto Founder and Managing Partner Chris Dixon breaks down his vision for a new internet, from using crypto to decentralize AI infrastructure and kickstart network effects, to why AI will be this era’s native form of media just as film was in the 1930s. He also explores why the internet’s original covenant—where content creators traded free access for search traffic—is breaking today, and how a better internet could introduce entirely new business models for creators.

Right now, we have a choice to make: will the next era of the internet be shaped by a handful of centralized players, or transformed into an open ecosystem where power and control flow to creators across the globe?

Read more, including a full transcript, here: https://a16z.com/ai-crypto-internet-chris-dixon/

[00:00:30] How technology evolves

[00:02:54] How crypto and AI interact

[00:08:39] Breaking the economic pact of the internet

[00:12:57] From mobile, social, and cloud to crypto, AI, and hardware

[00:14:49] Using crypto to bootstrap network effects

[00:16:33] Is AI frosting or sugar?

[00:19:57] Come for the tool, stay for the network

[00:20:39] Skeuomorphic vs. native technologies

[00:26:07] AI as the creative substrate of our era

[00:30:11] Balancing supply and demand in AI

[00:35:03] What decides consumer adoption of AI?

[00:36:05] What is the ideal future state of the internet?

In our conversation series AI Revolution, we ask industry leaders how they’re harnessing the power of generative AI and steering their companies through the next platform shift. Find more content from our AI Revolution series on www.a16z.com/AIRevolution.

Chris Dixon’s book is now available in paperback at readwriteown.com.