mRNA Juices Your Immunity
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mRNA Juices Your Immunity
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MIT and Harvard immunologists now report a method for tricking your liver into rejuvenating an aging immune system in the journal Nature. They synthesized mRNA capable of triggering the synthesis of three key immune factors: DLL1, FLT-3, and IL-7.
Working in a mouse model where, as in humans, the immunity-energizing thymus gland flags with age, they utilized their mRNA to turn liver synthesis of these critical immune components if only for a short time.
Even that limited time is sufficient for these geriatric mice to produce twice as many T cells and to respond significantly better to cancer checkpoint inhibitor immunotherapy. More work needs to be done to extend the effectiveness of the mRNA and the duration of immune factor production by the liver.
Even so, this technique shows promise for re-energizing the immunity of elders and extending life expectancy.
https://www.sciencedaily.com/releases/2025/12/251227082718.htm#google_vignette
https://www.nature.com/articles/s41586-025-09873-4
#mRNA #immunity #aging #liver #immunotherapy