Dr. Jonathan Downar, Psychiatrist and Associate Professor at the University of Toronto, joins neurocare’s Dr. Trevor Brown to discuss a groundbreaking new approach to Transcranial Magnetic Stimulation (TMS). The "ONE-D Trial" explores an accelerated, single-day TMS protocol designed to optimize neuroplasticity and enhance treatment outcomes for depression.

Unlike traditional TMS protocols requiring weeks of daily sessions, the ONE-D protocol delivers 20 sessions of intermittent theta burst stimulation (iTBS) over a single day, combined with D-cycloserine to boost neuroplasticity. Early findings indicate a delayed but robust treatment response, with remission rates increasing over six weeks post-treatment.

In this conversation, Dr. Downar explains the methodology, patient selection, and future implications of this innovative approach. They discuss how the ONE-D protocol compares to existing accelerated methods like the Stanford SAINT protocol and explore its potential applications for OCD, anxiety, and neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease.

About Dr. Jonathan Downar
Dr. Downar is an Associate Professor at the University of Toronto and a leading researcher in neuromodulation and accelerated TMS protocols. His work focuses on refining non-invasive brain stimulation techniques to improve accessibility and clinical efficacy.

About the series
The neurocare group is a global network of experts in neuroscience, psychology, and neuromodulation, dedicated to advancing mental health and performance science. In this interview series, neurocare Academy lead Dr Trevor Brown interviews leading minds in this field on the state of research and effective models of care in mental health and cognitive performance. To learn more about the neurocare group and its mission visit www.neurocaregroup.com.

Are you a practitioner interested in learning how you can apply TMS and other neuromodulation techniques in your own practice? Get started with one of our online courses in neuromodulation at: www.lms.neurocaregroup.com. neurocare academy also offers in-person training and supervision in workshops throughout the world. For more information visit: www.neurocaregroup.com/academy/

If you are a patient looking for more information about these techniques or to find one of our clinics worldwide, visit www.neurocaregroup.com/patients/

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In this episode of NeuroCare Academy, I sit down with Dr. Shan Siddiqi, a psychiatrist and lecturer at Harvard Medical School, to explore the future of psychiatry and neuromodulation. Dr. Siddiqi, a leading researcher in transcranial magnetic stimulation (TMS), shares insights from his latest work on TMS treatment for depression and its potential as an accredited subspecialty in medical education. We discuss the recent Brain Stimulation Subspecialty Summit, where experts aimed to standardize training and promote collaboration between psychiatry, neurology, and neurosurgery. This conversation highlights the importance of TMS in mental health care and the exciting developments on the horizon that could enhance clinical practice and patient outcomes. Tune in to learn more about the future of brain stimulation and its impact on mental health treatment.

Professor Alexander T. Sack, Cognitive Neuroscientist at Maastricht University, discusses how our understanding of the working mechanisms behind Transcranial Magnetic Stimulation (TMS) is evolving and what this means for improving clinical outcomes. Rather than focusing solely on precise stimulation sites using fMRI, Prof. Sack explains why optimizing the timing of pulses with EEG guidance may be key to enhancing treatment success.

In this conversation with Dr. Trevor Brown, Neuroscientist at neurocare group, they explore the importance of keeping a patient’s brain state active and consistent before and during TMS. By aligning treatment with brain-state dynamics, clinicians may be able to significantly increase therapeutic benefits.

Watch as they discuss the future of TMS, the science behind its working mechanisms, and how these insights could refine clinical practice for better patient outcomes.

About Prof. Alexander T. Sack:
Professor of Cognitive Neuroscience at Maastricht University, Prof. Alexander T. Sack specializes in non-invasive brain stimulation, particularly TMS and EEG, to study and enhance cognitive functions and clinical treatments.

About the series
The neurocare group is a global network of experts in neuroscience, psychology, and engineering, with a mission to empower best practices and bring innovative and sustainable mental health techniques to more patients in need through our network of clinics.

Through this interview series, the head of the neurocare Academy, Dr Trevor Brown, interviews leading minds in this field, to present the state of research and possibilities and effective models of care in mental health and cognitive performance.

To learn more about the neurocare group and its mission visit www.neurocaregroup.com

If you are a patient looking for more information about these techniques or to find one of our clinics worldwide, visit www.neurocaregroup.com/patients/

Are you a practitioner interested in learning how you can apply TMS and other neuromodulation techniques in your own practice?
Get started with one of our online courses in neuromodulation at: www.lms.neurocaregroup.com

neurocare academy also offers in-person training and supervision in workshops throughout the world. For more information visit: www.neurocaregroup.com/academy/


#TMS #rTMS #MagneticStimulation #TranscranialMagneticStimlation #Neurostimulation #ClinicalCare #Psychiatry #Nursing #psychology #neuroscience #MentalHealth #TMSClinic #DepressionTreatment #HealthcareProfessionals #ProfessionalSupervision #PatientDoctorRelationship #TherapeuticRelationship