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Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

To the student nurses at The Nightingale hospital, the ward sisters are heartless and frightening, with impossibly high standards. But the sisters have troubles of their own...Dora, the student nurse is struggling with her heartbreak over Nick, the man who got away. A new arrival on the ward brings the chance to put a smile back on her face. But can she really get over Nick so easily? Dora's fellow student Millie is also torn between the two men in her life.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Dora and her old enemy Lucy are paired up on the children's ward for the final three months of their training. The two nurses couldn't seem more different, but they may have more in common than they think, as each hides a secret heartache. And there are new faces. Jess is the feisty eldest daughter of a notorious East End family and determined to prove herself as a ward maid. New trainee nurse Effie can't wait to escape her small Irish village, and make her way as a nurse in London.

It's the final year of training for three young nurses at The Nightingale Hospital. Helen is at a crossroads in her life as she battles with her domineering mother over both her love life and her future career. Dora can't stop loving Nick, who is married to her best friend, Ruby. Millie is anxious about her fiancé, sent to Spain to cover the Civil War, and things only get worse when she encounters a fortune teller who gives her a sinister warning.

Spring, 1941. The families of Jubilee Row are still reeling from the loss of one of their own, and as the Blitz on Hull intensifies, it seems as if there will be more tragedies to come. As the street braces itself, capable mum Ruby Maguire takes charge as usual, bolstering spirits and lending a hand, as well as keeping her flighty sister Pearl on the straight and narrow. But the unexpected appearance of a face from her past threatens Ruby's future far more than Hitler's bombs. Meanwhile, the other inhabitants of Jubilee Row are finding love - and hope - in the most unexpected places.

As the war takes its toll, the Nightingale nurses must do their bit for king and country... Dora is the devoted mother of twin babies, but, determined to help the war effort, she goes back to work at the Nightingale Hospital. More used to nights out in the West End, Jennifer and Cissy volunteer in the hope of tending to handsome soldiers. They soon find out that nursing isn’t quite what they were expecting.

Matron Kathleen Fox has the job of putting the hospital back together but wonders if she is up to the task. In an attempt to bring some festive cheer, she decides to put on a Christmas show. The idea is greeted with mixed feelings by the nurses, who all have their own problems, and also by the new Assistant Matron and ward sister, who find themselves rivals for the role of organiser. But as rehearsals begin, the performers begin to find the show is not just a tonic for the patients.

Hull, 1940. Widowed Edie Copeland has just arrived on Exchange Street, heavily pregnant and with heavy suitcase in tow. She left York after tragedy struck to make a fresh start, but she's a stranger to this street, and her new landlord doesn't hesitate to remind her of this, widow or not. Luckily, the neighbours are a little more welcoming and Edie is soon made to feel at home by the Maguires and the Scuttles. As air raids sound and the war feels closer than ever, the community has to stick together. But Edie is hiding something, and she doesn't know how much longer her secret is safe.

Anna is over the moon when her sweetheart returns from the front line. As he recovers from his injuries, they make plans to be married, but the horrors of the trenches cast a long shadow. Caring for shell-shocked soldiers brings untold challenges for Grace, and her parents have very different dreams for her future. Meanwhile Dulcie has her sights firmly set on her own happy ending. And yet sometimes we find love where we least expect to. Each of the nurses has her own battle to fight, but they must rally together if they’re to find true happiness.

London, 1914. While young men enlist up and down the country, the Nightingale Hospital has its own set of new recruits.... Anna Beck is the daughter of the best baker in Bethnal Green. Her German father built the business out of nothing, but as the shadow of war descends, his fate is at the mercy of their neighbours. Meanwhile Katie Carlyle has always wanted to become a doctor. She fought hard to get into medical school, and even now she faces prejudice from her fellow students as well as the tutors. Can she prove them wrong?

As Christmas 1938 approaches, the staff at the Nightingale Hospital have their own wishes for the festive season. Ward sister Frannie Wallace is hoping she won't have to live through another war like the one that claimed her fiance. Staff Nurse Helen Dawson wants to find happiness again after the death of her husband Charlie. But is she looking for love in the wrong place? Matron Kathleen Fox struggles to keep up morale.

With her husband, Nick, away fighting, Dora struggles to keep the home fires burning but finds herself in a difficult position when she is put in charge of a ward of injured German POWs. Can she find it in her heart to care for her enemies? Fellow nurse Kitty faces a similar struggle looking after the men who killed her beloved brother. But her life becomes even more complicated when she falls for one of the prisoners. And Helen Denton returns from nursing in Europe with a secret. She has her own reasons for hating the Germans.

It's Christmas 1941, and the nurses at the Nightingale are facing their toughest winter yet. With shortages everywhere and every news bulletin announcing more losses, the British people are weary and demoralised, and The Nightingale Hospital is suffering too. Millie is recently widowed and dealing with the demands of her family's estate. It's not long before her old world of the Nightingale begins to beckon, along with a long-lost love.... Jess is struggling with her move from East London to the countryside.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Christmas Eve, 1936. On a foggy December night, a pregnant woman walks out in front of a trolley bus and is knocked unconscious. She is rushed to the Nightingale hospital, and a healthy baby is delivered. But the mother claims to have lost her memory, and cannot believe that the child is hers. It seems that the Nightingale nurses may need to perform a Christmas miracle.

It's 1957, and three young women are beginning their nursing training at the Florence Nightingale Hospital in London's East End. Winne desperately wants to win her mother's approval - but will following in her footsteps and becoming a nurse help? Tearaway Viv has never been one to follow the rules, though the Nightingale may help her mend her ways. Beth is following her late sister's dream by training as a nurse. Will it be the right path for her? There's a steep learning curve ahead. But with friendship on their side, the Nightingale Daughters are ready to rise to the challenge.

Autumn, 1942. The Blitz has come to an end, but for many families, it's not over yet. As the residents of Jubilee Row begin to rebuild their lives, twins Sybil and Maudie Maguire decide to go off and do their bit by joining the WAAFs. But what starts off as a great adventure soon forces the girls to grow up as they are confronted with the harsh realities of war. Will they stick together, or will their experiences drive them apart? Back in Hull, their older sister Florence is a typing pool supervisor who has resigned herself to a life without love.

London, 1917. Anna ist überglücklich, als ihr geliebter Edward von der Front zurückkehrt. Während die beiden eifrig Hochzeitspläne schmieden, muss ihre Freundin Grace sich gegen ihre Eltern behaupten. Die Pflege verwundeter Soldaten ist nicht das, was diese sich als Zukunft für ihre Tochter wünschen. Dulcie indessen scheint ihr Glück gefunden zu haben, als eine unverhoffte Begegnung sie erkennen lässt: Manchmal begegnet einem die Liebe genau da, wo man sie am wenigstens erwartet.

London, 1914. Als drei junge Frauen ihre Ausbildung am Londoner Nightingale Hospital beginnen, geht für jede von ihnen ein Traum in Erfüllung. Doch für ihr persönliches Glück müssen sie Opfer bringen. Während die aus einfachsten Verhältnissen stammende Sadie alles daransetzt, ihre Herkunft zu verbergen, erfährt Sonnenschein Anna zum ersten Mal, was es heißt, nicht dazuzugehören. Und Kate, die wie ihre Brüder Medizin studieren will, muss gegen den erbitterten Widerstand ihres Vaters kämpfen.