Race Evolution

Early one morning in the summer of 1999, authorities in the tiny West Texas town of Tulia began a roundup of suspected drug dealers. By the time the sweep was done, over 40 people had been arrested and one of every five black adults in town was behind bars, all accused of dealing cocaine to the same undercover officer, Tom Coleman.

Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.

A vibrant young Hispano woman, Shonnie Medina, inherits a breast-cancer mutation known as BRCA1.185delAG. It is a genetic variant characteristic of Jews. The Medinas knew they were descended from Native Americans and Spanish Catholics, but they did not know that they had Jewish ancestry as well. The mutation most likely sprang from Sephardic Jews hounded by the Spanish Inquisition. The discovery of the gene leads to a fascinating investigation of cultural history and modern genetics by Dr. Harry Ostrer and other experts on the DNA of Jewish populations.

This dynamic chronicle of the race to find the "missing links" between humans and apes transports readers into the highly competitive world of fossil hunting and into the lives of the ambitious scientists intent on pinpointing the dawn of humankind. The quest to find where and when the earliest human ancestors first appeared is one of the most exciting and challenging of all scientific pursuits.

Everyone has heard the story of DNA as the story of Watson, Crick, and Rosalind Franklin, but knowing the structure of DNA was only part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had far-reaching consequences for how we understand ourselves and our place in the natural world.

At a conference in Hong Kong in November 2018, Dr. He Jiankui announced that he had created the first genetically modified babies - twin girls named Lulu and Nana - sending shockwaves around the world. A year later, a Chinese court sentenced Dr. He to three years in prison for "illegal medical practice". As scientists elsewhere start to catch up with China's vast genetic research program, gene editing is fueling an innovation economy that threatens to widen racial and economic inequality. Fundamental questions about science, health, and social justice are at stake.