Chemist Elizabeth Zott is not your average woman. In fact, Elizabeth Zott would be the first to point out that there is no such thing as an average woman. But it’s the early 1960s and her all-male team at Hastings Research Institute takes a very unscientific view of equality. Except for one: Calvin Evans; the lonely, brilliant, Nobel–prize nominated grudge-holder who falls in love with—of all things—her mind. True chemistry results. But like science, life is unpredictable.

Augustus Everett is an acclaimed author of literary fiction. January Andrews writes best-selling romance. When she pens a happily ever after, he kills off his entire cast. They’re polar opposites. In fact, the only thing they have in common is that for the next three months, they're living in neighboring beach houses, broke, and bogged down with writer's block.

Six years after the fight that ended their friendship, Daphne Berg is shocked when Drue Cavanaugh walks back into her life, looking as lovely and successful as ever, with a massive favor to ask. Daphne hasn’t spoken one word to Drue in all this time - she doesn’t even hate-follow her ex-best friend on social media - so when Drue asks if she will be her maid-of-honor at the society wedding of the summer, Daphne is rightfully speechless.

The Vignes twin sisters will always be identical. But after growing up together in a small, Southern Black community and running away at age 16, it's not just the shape of their daily lives that is different as adults, it's everything: Their families, their communities, their racial identities. Many years later, one sister lives with her Black daughter in the same Southern town she once tried to escape. The other secretly passes for White, and her White husband knows nothing of her past.

On the eve of her 40th birthday, Alice’s life isn’t terrible. She likes her job, even if it isn’t exactly the one she expected. She’s happy with her apartment, her romantic status, her independence, and she adores her lifelong best friend. But her father is ailing, and it feels to her as if something is missing. When she wakes up the next morning she finds herself back in 1996, reliving her 16th birthday.

Bea Schumacher is a devastatingly stylish plus-size fashion blogger who has amazing friends, a devoted family, legions of Insta followers - and a massively broken heart. Like the rest of America, Bea indulges in her weekly obsession: the hit reality show Main Squeeze. The fantasy dates! The kiss-off rejections! The surprising amount of guys named Chad! But Bea is sick and tired of the lack of body diversity on the show. Since when is being a size zero a prerequisite for getting engaged on television? Just when Bea has sworn off dating altogether, she gets an intriguing call.

Elisabeth, an accomplished journalist and new mother, is struggling to adjust to life in a small town after nearly 20 years in New York City. Alone in the house with her infant son all day (and awake with him much of the night), she feels uneasy, adrift. She neglects her work, losing untold hours to her Brooklyn moms' Facebook group, her "influencer" sister's Instagram feed, and text messages with the best friend she never sees anymore.  Enter Sam, a senior at the local women's college, whom Elisabeth hires to babysit.

Alix Chamberlain is a woman who gets what she wants and has made a living, with her confidence-driven brand, showing other women how to do the same. So she is shocked when her babysitter, Emira Tucker, is confronted while watching the Chamberlains' toddler one night, walking the aisles of their local high-end supermarket. The store's security guard, seeing a young Black woman out late with a White child, accuses Emira of kidnapping two-year-old Briar. A small crowd gathers, a bystander films everything, and Emira is furious and humiliated. Alix resolves to make things right.

Sophie Honeywell always wondered if Thomas Gordon was the one who got away. He was the perfect boyfriend, but on the day he was going to propose, she broke his heart. A year later, he married his travel agent, while Sophie has been mortifyingly single ever since. Now, Thomas is back in her life because Sophie has unexpectedly inherited his aunt Connie's house on Scribbly Gum Island - home of the famously unsolved Munro Baby mystery.

Julian Jessop, an eccentric, lonely artist and septuagenarian believes that most people aren’t really honest with each other. But what if they were? And so he writes - in a plain, green journal - the truth about his own life and leaves it in his local café. It’s run by the incredibly tidy and efficient Monica, who furtively adds her own entry and leaves the book in the wine bar across the street. Before long, the others who find the green notebook add the truths about their own deepest selves - and soon find each other In Real Life at Monica’s Café.