Mara, Sadie, and Hannah are friends first, scientists always. Though their fields of study might take them to different corners of the world, they can all agree on this universal truth: When it comes to love and science, opposites attract and rivals make you burn….

Viola Bowen has the chance of a lifetime: to design a video game based on her all-time favorite book series. The only problem? Her co-lead is Jesse F-ing Andrews, a.k.a. her arch-nemesis. Jesse has made it abundantly clear over the years that he wants nothing to do with her–and Viola has no idea why. When their bosses insist a wintery retreat is the perfect team-building exercise, Viola can’t think of anything worse. Being freezing cold in a remote mountain lodge knowing Jesse is right next door? No, thank you.

Like an avenging, purple-haired Jedi bringing balance to the mansplained universe, Bee Königswasser lives by a simple code: What would Marie Curie do? If NASA offered her the lead on a neuroengineering project—a literal dream come true after years scraping by on the crumbs of academia—Marie would accept without hesitation. Duh. But the mother of modern physics never had to co-lead with Levi Ward.

All newly minted pediatrician Jamie Malek wants is to borrow a roasting pan for Christmas dinner. Unfortunately, that requires her to interact with Marc—her best friend’s troublemaking brother, who’s now a tech billionaire. He’s the one who got away. She’s the one who broke his heart. Outside, a howling blizzard. Inside, a crackling fire. Suddenly, being snowbound with the man she never expected to see again might not be such a bad way to spend a winter’s night.

Rue Siebert might not have it all, but she has enough: a few friends she can always count on, the financial stability she yearned for as a kid, and a successful career as a biotech engineer at Kline, one of the most promising start-ups in the field of food science. Her world is stable, pleasant, and hard-fought. Until a hostile takeover and its offensively attractive front man threatens to bring it all crumbling down.

Mallory Greenleaf is done with chess. Every move counts nowadays; after the sport led to the destruction of her family four years earlier, Mallory’s focus is on her mom, her sisters, and the dead-end job that keeps the lights on. That is, until she begrudgingly agrees to play in one last charity tournament and inadvertently wipes the board with notorious “Kingkiller” Nolan Sawyer: current world champion and reigning Bad Boy of chess.

Chandler Cohen has never felt more like the ghost in "ghostwriter" until she attends a signing for a book she wrote—and the author doesn’t even recognize her. The evening turns more promising when she meets a charming man at the bar and immediately connects with him. But when all their sexual tension culminates in a spectacularly awkward hookup, she decides this is one night better off forgotten. Unfortunately, that’s easier said than done.

As a third-year PhD candidate, Olive Smith doesn't believe in lasting romantic relationships—but her best friend does, and that's what got her into this situation. Convincing Anh that Olive is dating and well on her way to a happily ever after was always going to take more than hand-wavy Jedi mind tricks: Scientists require proof. So, like any self-respecting biologist, Olive panics and kisses the first man she sees.

Wells Whitaker was once golf’s hottest rising star, but lately, all he has to show for his “promising” career is a killer hangover, a collection of broken clubs, and one remaining supporter. No matter how bad he plays, the beautiful, sunny redhead is always on the sidelines. He curses, she cheers. He scowls, she smiles. But when Wells quits in a blaze of glory and his fangirl finally goes home, he knows he made the greatest mistake of his life.

The proposition is simple: if ER nurse Claire Harper and her roommate, firefighter Graham Scott, are still single by the time they’re forty, they’ll take the proverbial plunge together…as friends with benefits. Maybe it’s the wine, but in the moment, Claire figures the pact is a safe-enough deal, considering she hasn’t had much luck in love and he’s in no rush to settle down. Like, at all. Besides, there’s no way she could ever really fall for Graham and his thrill-seeking ways. Not after what happened to her father.