In 1909, Clementine steps off a train with her new husband, Winston. An angry woman emerges from the crowd to attack, shoving him in the direction of an oncoming train. Just before he stumbles, Clementine grabs him by his suit jacket. This will not be the last time Clementine Churchill will save her husband. Lady Clementine is the ferocious story of the ambitious woman beside Winston Churchill, the story of a partner who did not flinch through the sweeping darkness of war, and who would not surrender either to expectations or to enemies.

Her beauty almost certainly saved her from the rising Nazi party and led to marriage with an Austrian arms dealer. Underestimated in everything else, she overheard the Third Reich's plans while at her husband's side, understanding more than anyone would guess. She devised a plan to flee in disguise from their castle, and the whirlwind escape landed her in Hollywood. She became Hedy Lamarr, screen star.

Mitza Maric has always been a little different from other girls. Most 20-year-olds are wives by now, not studying physics at an elite Zurich university with only male students trying to outdo her clever calculations. But Mitza is smart enough to know that, for her, math is an easier path than marriage. And then fellow student Albert Einstein takes an interest in her, and the world turns sideways. Theirs becomes a partnership of the mind and of the heart, but there might not be room for more than one genius in a marriage.

In her twenties, Belle da Costa Greene is hired by J. P. Morgan to curate a collection of rare manuscripts, books, and artwork for his newly built Pierpont Morgan Library. Belle becomes a fixture in New York City society and one of the most powerful people in the art and book world, known for her impeccable taste and shrewd negotiating for critical works as she helps create a world-class collection.

Rosalind Franklin has always been an outsider - brilliant, but different. Whether working at the laboratory she adored in Paris or toiling at a university in London, she feels closest to the science, those unchanging laws of physics and chemistry that guide her experiments. When she is assigned to work on DNA, she believes she can unearth its secrets. Rosalind knows if she just takes one more X-ray picture - one more after thousands - she can unlock the building blocks of life.