Cursed by an extreme and unrelenting beauty, Adrian has drawn the frenzied attention of adoring strangers since childhood. As a 29-year-old in New York City, he spends his days drifting between affairs with women (and occasionally men) who provide him with everything he needs, from spending money to luxurious vacations to even, once, a mini yacht. With this generosity comes a dangerous possessiveness that often puts him at risk of much worse than heartbreak. But as people begin removing their masks in the spring of 2021, Adrian's aimless sexual availability is interrupted by a shocking discovery: He is no longer beautiful.

Across the country, Adrian's best friend and companion, Mark, a world-famous painter, has returned to the family home in rural Northern California. He's faced with his own horrible revelation: He's dying from the same mysterious disease that will soon take his mother and sister.

Despite the depth of their platonic romance, neither man reveals his fate to the other. Feeling as if he's disappearing from sight, Adrian searches for answers among his thousands of lovers. In a race against his failing body, Mark becomes obsessed with watching 52 VHS tapes of unknown origin, left to him by his sister, before it's too late.