When two hikers go missing within a series of daunting caves outside of Denver, Colorado, FDLE special agent Amy Larson and her partner, FBI special agent Hunter Forrest, have good reason to suspect foul play. The pair of hikers are only the latest to vanish after a rash of disappearances that’s left local law enforcement stumped. But in searching the dank caverns near the Arkansas River, the agents aren’t prepared for the horror they uncover: a muddy pit littered with corpses. Covered in bite marks. Made by human teeth.

A secret government unit is formed under the oversight of Adam Harrison, famed paranormal investigator. The case: In a historic mansion in New Orleans’ French Quarter, a senator’s wife falls to her death from a balcony. Most think she jumped, distraught over the loss of her young son. Some say she was pushed. And yet others believe she was beckoned by the ghostly spirits that inhabit the house - once the site of a serial killer’s grisly work.

A ritualistic murder on the side of a remote road brings in the Florida state police. Special Agent Amy Larson has never seen worse, and there are indications that this killing could be just the beginning. The crime draws the attention of the FBI in the form of Special Agent Hunter Forrest, a man with insider knowledge of how violent cults operate, and a man who might never be able to escape his own past.

It's a pub in lower Manhattan, run by the Finnegan family for generations and now owned by Kieran and her three brothers. Kieran Finnegan, who still works there whenever she can, has become a criminal psychologist - a fitting reaction, perhaps, to her less-than-lawful past. Meanwhile, New York's Diamond District has been hit by a rash of thefts. No one's been killed - until now.

Four bodies have been discovered along Europe’s riverbanks, placed with care—and completely drained of blood. Pinpricks on their throats indicate a slender murder weapon, but DNA found in the wounds suggests something far more sinister. Tasked with investigating, the FBI recruits Agents Della Hamilton and Mason Carter to Blackbird, an international offshoot of the Krewe of Hunters. If you want to catch a vampire killer, you need agents who can speak with the dead.