Deep Medicine

The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".

For too long, scientists have focused on the dark side of our biological heritage: our capacity for aggression, cruelty, prejudice, and self-interest. But natural selection has given us a suite of beneficial social features, including our capacity for love, friendship, cooperation, and learning. Beneath all our inventions - our tools, farms, machines, cities, nations - we carry with us innate proclivities to make a good society. 

In The Patient Will See You Now, Eric Topol, one of the nation's top physicians, examines what he calls medicine's "Gutenberg moment". Much as the printing press liberated knowledge from the control of an elite class, new technology is poised to democratize medicine. In this new era, patients will control their data and be emancipated from a paternalistic medical regime in which "the doctor knows best."

Artificial intelligence does the seemingly impossible - driving cars, trading stocks, and teaching children. But facing the sea change that AI will bring can be paralyzing. How should companies set strategies, governments design policies, and people plan their lives for a world so different from what we know? In Prediction Machines, three eminent economists recast the rise of AI as a drop in the cost of prediction. With this single, masterful stroke, they lift the curtain on the AI-is-magic hype and show how basic tools from economics provide clarity about the AI revolution and a basis for action by CEOs, managers, policy makers, investors, and entrepreneurs.

How will artificial intelligence affect crime, war, justice, jobs, society, and our very sense of being human? The rise of AI has the potential to transform our future more than any other technology - and there's nobody better qualified or situated to explore that future than Max Tegmark, an MIT professor who's helped mainstream research on how to keep AI beneficial.

How Can I Help? portrays a week in the life of Dr. David Goldbloom as he treats patients, communicates with families, and trains staff at CAMH, the largest psychiatric facility in Canada. This highly listenable and touching behind-the-scenes account of his daily encounters with a wide range of psychiatric concerns - from his own patients and their families to Emergency Department arrivals - puts a human face on an often misunderstood area of medical expertise.

It is worse, much worse, than you think. If your anxiety about global warming is dominated by fears of sea-level rise, you are barely scratching the surface of what terrors are possible. Like An Inconvenient Truth and Silent Spring before it, The Uninhabitable Earth is both a meditation on the devastation we have brought upon ourselves and an impassioned call to action. For just as the world was brought to the brink of catastrophe within the span of a lifetime, the responsibility to avoid it now belongs to a single generation. 

Under the aegis of machine learning in our data-driven machine age, computers are programming themselves and learning about - and solving - an extraordinary range of problems, from the mundane to the most daunting. Today it is machine learning programs that enable Amazon and Netflix to predict what users will like, Apple to power Siri's ability to understand voices, and Google to pilot cars.

In Being Mortal, bestselling author Atul Gawande tackles the hardest challenge of his profession: how medicine can not only improve life but also the process of its ending. Medicine has triumphed in modern times, transforming birth, injury, and infectious disease from harrowing to manageable. But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit.

Our health care system is in critical condition. The Affordable Care Act has insured more Americans than ever, yet deductibles keep rising and costs continue to climb. Now more than ever, the industry needs a shot in the arm. It needs The Innovator's Prescription, the now-classic approach to efficient, affordable health care.

Most startups fail. But many of those failures are preventable. The Lean Startup is a new approach being adopted across the globe, changing the way companies are built and new products are launched.

Everyone knows that timing is everything. But we don't know much about timing itself. Our lives are a never-ending stream of "when" decisions: when to start a business, schedule a class, get serious about a person. Yet we make those decisions based on intuition and guesswork. Timing, it's often assumed, is an art. In When: The Scientific Secrets of Perfect Timing, Pink shows that timing is really a science.

Utopia for Realists is one of those rare books that takes you by surprise and challenges what you think can happen. From a Canadian city that once completely eradicated poverty to Richard Nixon's near implementation of a basic income for millions of Americans, Bregman takes us on a journey through history and beyond the traditional left-right divides as he champions ideas whose time has come.

Homo Deus explores the projects, dreams, and nightmares that will shape the 21st century - from overcoming death to creating artificial life. It asks the fundamental questions: Where do we go from here? And how will we protect this fragile world from our own destructive powers? This is the next stage of evolution. This is Homo Deus.