Captain Mal Reynolds is in a fix. He’d like nothing more than to find honest smuggling work that stays under the Alliance’s radar and keeps the good ship Serenity in the sky. But when an old flame of Jayne Cobb’s sends a desperate plea across the galaxy, his crew has other ideas. On the arid, far-flung world of Thetis, the terrifying Elias Vandal is threatening to overrun the town of Coogan’s Bluff with his trigger-happy army. He wants control of the only thing standing between its people and dustbowl ruin: their water supply.

Mal wins an old map in a card game. Ancient and written in impenetrable symbols, the former owner insists it's worthless. Yet River Tam can read it, and says it leads to one of the Arks - legendary ships that brought humans from Earth-that-was to the 'Verse. The salvage potential alone is staggering. But the closer they get to the ancient ship, the more agitated River becomes.

Neapolis: a desert city on planet Bethel where all manner of entertainment is found: High-stakes gambling, luxurious hotels, exclusive clubs, and any form of diversion imaginable may be had for a price. It’s the eve of the annual carnival: three days of decadent revelry, and Serenity arrives to take a security job, guarding a costly shipment. But the shipment is stolen, and the wealthy owner kidnaps Zoë and Book, holding them to ransom for the lost shipment’s value. If Mal can’t find the enormous sum of 500 platinum by the next evening, both of them will be killed.

Months after Inara leaves Serenity, Mal and the crew finally learn the reason for her sudden departure: She is dying of a terminal illness. Expert Esau Weng is said to have developed a means to treat Inara’s condition, but he has been disgraced and incarcerated for life on a notorious Alliance prison planet. On Atata planet, inmates are abandoned with no guards and left to survive as best they can. What’s more, terraforming the planet did not take properly, so the world is a frozen wasteland. To save Inara, the Serenity crew must infiltrate the prison....

The Battle of Serenity Valley was the turning point that led the Independents to their defeat at the hands of the Alliance. Yet the Browncoats had held the valley for weeks against all odds, before being ordered to lay down their arms. Command stated they refused to send in airpower because the ground war was "too hot". But the soldiers who were there insist that was not true.... While picking up a new cargo on Persephone, Captain Malcolm Reynolds is kidnapped by a bunch of embittered veteran Browncoats who suspect him of sabotaging the Independents during the war.