The Inquisition moves amongst mankind like an avenging shadow, striking down the enemies of humanity with uncompromising ruthlessness. When he finally corners an old foe, Inquisitor Gregor Eisenhorn is drawn into a sinister conspiracy. As events unfold and he gathers allies - and enemies - Eisenhorn faces a vast interstellar cabal and the dark power of daemons, all racing to recover an arcane text of abominable power: an ancient tome known as the Necroteuch.

On an Imperial outpost world on the fringes of tau space, the renowned Commissar Ciaphas Cain and his fractious regiment of Valhallan Guard, newly created from the remnants of two devastated units, find themselves in the middle of a war. As the Astra Militarum struggle to contain worldwide civil insurrection, can the wily Commissar Cain identify the real villain before the planet is lost to the Imperium forever?

For Ianthe, war is all too familiar. A former soldier in the Astra Militarum, she now serves Inquisitor Covenant as an agent of the Throne. Her first mission sees her investigating a cult called the Children of Eternity. Falling foul of the local Enforcers, Ianthe soon learns that war in the shadows is seldom straightforward and that the local, angry law-keepers are the least of her troubles.

Before the being called the Emperor revealed himself, before the rise of the aeldari, before the necrontyr traded their flesh for immortal metal, the world was born in violence. Even when they inhabited bodies of flesh, Trazyn the Infinite and Orikan the Diviner were polar opposites. Trazyn, a collector of historical oddities, presides over a gallery full of the most dangerous artefacts - and people - of the galactic past. Orikan, a chronomancer without peer, draws zodiacs that predict and manipulate the future. 

The Night Lords were once among the most potent forces of the Imperium, Space Marines who used fear itself as their weapon. Now, cast adrift from the Emperor's light and hunted as heretics after their monstrous betrayal, the Night Lords clad themselves in symbols of death and fight the Long War, bringing pain and terror to all who worship the corpse-god of Terra. A summons from Warmaster Abaddon sends these rebels on a dangerous journey that leads inexorably to a conflict with the Emperor's chosen warriors, the Blood Angels.  

Ufthak Blackhawk and the green tide descend upon Hephaesto - an Adeptus Mechanicus forge world bristling with loot - only to find it already under siege by the notorious Freebooter Kaptin Badrukk. When his warboss, Da Biggest Big Mek, orders temporary co-operation, Ufthak seeks to make a name for himself by crushing some of the Imperium’s most advanced defenders and claiming the greatest prize. 

After seven long years of conflict, the Horus Heresy nears its end. But now, as the Warmaster Horus marches on Terra to rip his father from the Throne, the seat of the arch-traitor’s power lies empty. Cthonia, a world once dominated by brutal murder-gangs, is occupied by the Emperor’s praetorians—the indomitable Imperial Fists. For the Sons of Horus, this outrage demands a reckoning. 

Exile to the miserable world of Sedh, the disgraced Necron Lord Oltyx is consumed with bitterness. Once heir to the throne of a dynasty, he now commands nothing but a dwindling garrison of warriors, in a never-ending struggle against Ork invaders. Oltyx can think of nothing but the prospect of vengeance against his betrayers, and the reclamation of his birthright. But the Orks are merely the harbingers of a truly unstoppable force. Unless Oltyx acts to save his dynasty, revenge will win him only ashes. 

After seven years of bitter war, the end has come at last for the conflict known infamously as the Horus Heresy. Terra now lies within the Warmaster’s sights, the Throneworld and the seat of his father’s rule. Horus’ desire is nothing less than the death of the Emperor of Mankind and the utter subjugation of the Imperium. He has become the ascendant vessel of Chaos and amassed a terrible army with which to enact his will and vengeance. But the way to the Throne will be hard as the primarch Rogal Dorn, the Praetorian and protector of Terra, marshals the defences.

In the Pandorax System, on the death world of Pythos, an ancient secret that has laid buried for millennia. Ignorant of this terror, troopers of the Catachan 183rd, stranded on Pythos, find themselves under attack by the forces of Chaos. Daemons in their thousands flock the sky, and none other than Warmaster Abaddon leads the attack. With the Death Guard and Black Legion arrayed against them, the Catachans appear to be doomed, until salvation arrives in the form of the entire Dark Angels Chapter. But what is the so-called 'Damnation Cache'?